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  5. Cardiotrophin-1/CTF1 蛋白, Human (HEK293)

Cardiotrophin-1/CTF1 蛋白, Human (HEK293)

目录号: HY-P72870
产品使用指南

Cardiotropin-1/CTF1 蛋白通过结合并激活 ILST/gp130 受体在体外诱导心肌细胞肥大,突出了其在心肌细胞增大中的调节作用。这种参与协调了有助于肥厚反应的信号事件,提供了对心脏肥大机制的深入了解,并暗示了 Cardiotropin-1 在心肌生长中的作用。Cardiotrophin-1/CTF1 蛋白, Human (HEK293) 是重组的 心肌营养蛋白-1/CTF1 蛋白,由 HEK293 表达,不带标签。Cardiotrophin-1/CTF1 蛋白, Human (HEK293) 全长 200 个氨基酸,分子量约为 ~26.6 kDa。

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描述

Cardiotrophin-1/CTF1 protein induces cardiac myocyte hypertrophy in vitro by binding to and activating the ILST/gp130 receptor, highlighting its regulatory role in heart muscle cell enlargement. This engagement orchestrates signaling events that contribute to the hypertrophic response, providing insight into the mechanisms of cardiac hypertrophy and implicating Cardiotrophin-1 in heart muscle growth. Cardiotrophin-1/CTF1 Protein, Human (HEK293) is the recombinant human-derived Cardiotrophin-1/CTF1 protein, expressed by HEK293 , with tag free. The total length of Cardiotrophin-1/CTF1 Protein, Human (HEK293) is 200 a.a., with molecular weight of ~26.6 kDa.

研究背景

Cardiotropin-1/CTF1 蛋白在体外是心肌细胞肥大的有效诱导剂,强调了其在心肌细胞增大中的调节作用。这种效应是通过其与 ILST/gp130 受体的结合和激活介导的,表明 Cardiotropin-1 通过特定的分子途径发挥其影响。通过与 ILST/gp130 受体结合,Cardiotropin-1 协调信号事件,促进心肌细胞肥大反应。对 Cardiotropin-1 及其受体之间相互作用的分子洞察提供了对心脏肥大机制的基础了解,并表明该蛋白质与心肌生长的调节有关。

种属

Human

表达系统

HEK293

标签

Tag Free

蛋白编号

Q16619 (S2-A201)

基因 ID
蛋白结构
N-term
CTF1 (S2-A201)
Accession # Q16619
C-term
同用名
Cardiotrophin-1; CT-1; CTF1
氨基酸序列

SRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPSFSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLRRLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGLYREWLSRTEGDLGQLLPGGSA

分子量

Approximately 26.6 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Cardiotrophin-1/CTF1 Protein, Human (HEK293) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Cardiotrophin-1/CTF1 Protein, Human (HEK293)
目录号:
HY-P72870
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