1. 重组蛋白
  2. Cytokines and Growth Factors CAR-T related Proteins Receptor Proteins Enzymes & Regulators
  3. EGF Superfamily Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. EGFR/ErbB family
  5. EGFR
  6. EGFR 蛋白, Mouse (HEK293, Fc)

EGFR 蛋白, Mouse (HEK293, Fc)

目录号: HY-P72988
COA 产品使用指南

EGFR 蛋白是一种受体酪氨酸激酶,可结合 EGF 家族配体并激活多个信号级联。配体结合诱导受体同二聚或异二聚化,导致自身磷酸化和接头蛋白(例如 GRB2)的募集。EGFR 蛋白, Mouse (HEK293, Fc) 是重组的 EGFR 蛋白,由 HEK293 表达,带有 C-hFc 标签。EGFR 蛋白, Mouse (HEK293, Fc) 全长 623 个氨基酸,分子量约为 ~142.57 kDa。

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重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 μg ¥750 In-stock
50 μg ¥2100 In-stock
100 μg ¥3600 In-stock
500 μg ¥12000 In-stock
1 mg ¥20000 询价
> 100 μg   询价  

* Please select Quantity before adding items.

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描述

The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades. Ligand binding induces receptor homo- or heterodimerization, leading to autophosphorylation and recruitment of adapter proteins (such as GRB2). EGFR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EGFR Protein, Mouse (HEK293, Fc) is 623 a.a., with molecular weight of ~142.57 kDa.

研究背景

EGFR 蛋白是一种受体酪氨酸激酶,可结合 EGF 家族的配体,例如 EGF、TGFA/TGF-α、AREG、epigen/EPGN、BTC/betacellulin、epiregulin/EREG 和 HBEGF/肝素结合 EGF,激活多种信号传导级联将细胞外信号转导为细胞反应。配体结合诱导受体同二聚和/或异二聚化,导致关键细胞质残基的自磷酸化。磷酸化受体招募 GRB2 等衔接蛋白,启动下游信号级联,包括 RAS-RAF-MEK-ERK、PI3 激酶-AKT、PLCgamma-PKC 和 STAT 模块。EGFR 还可能激活 NF-kappa-B 信号级联并直接磷酸化 RGS16 等蛋白质,从而调节 G 蛋白偶联受体信号传导。此外,EGFR 磷酸化 MUC1,增强其与 SRC 和 CTNNB1/β-连环蛋白的相互作用。值得注意的是,它通过与 CCDC88A/GIV 相互作用积极调节细胞迁移,促进 EGFR 信号传导并触发细胞迁移。EGFR 还在增强学习和记忆能力方面发挥作用,并有助于哺乳动物的疼痛信号传导,从而导致持久的超敏反应。

生物活性

Immobilized Mouse EGFR, at 1 μg/mL (100 μL/well) can bind Anti- EGFR Antibody. The ED50 is 0.7847 ng/mL, corresponding to a specific activity is 1.27×106 U/mg.

  • Immobilized Mouse EGFR, at 1 μg/mL (100 μL/well) can bind Anti- EGFR Antibody. The ED50 is 0.7847 ng/mL, corresponding to a specific activity is 1.27×106 U/mg.
种属

Mouse

表达系统

HEK293

标签

C-hFc

蛋白编号

Q01279 (L25-S647)

基因 ID
蛋白结构
N-term
EGFR (L25-S647)
Accession # Q01279
hFc
C-term
同用名
Epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1
氨基酸序列

LEEKKVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPS

分子量

Approximately 142.57 kDa

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
EGFR Protein, Mouse (HEK293, Fc)
目录号:
HY-P72988
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