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  4. FcγRIIIB/CD16b CLM-7/CD300b Fc gamma RIII/CD16
  5. Fc gamma RIIIB/CD16b 蛋白, Human

Fc gamma RIIIB/CD16b 蛋白, Human

目录号: HY-P75206
产品使用指南

Fc gamma RIIIB/CD16b 蛋白是 IgG 的低亲和力受体,可结合复合或单体 IgG。与 Fc gamma RIIIA 不同,它不能介导抗体依赖性细胞毒性或吞噬作用。相反,Fc gamma RIIIB 可能充当免疫复合物的陷阱,在不激活中性粒细胞的情况下进行循环。它作为单体存在,与 INPP5D/SHIP1 相互作用,这意味着它在与免疫反应相关的细胞内信号传导途径中发挥作用。Fc gamma RIIIB/CD16b 蛋白, Human 是重组的 Fc gamma RIIIB/CD16b 蛋白,由 E. coli 表达,不带标签。Fc gamma RIIIB/CD16b 蛋白, Human 全长 176 个氨基酸,分子量约为 ~22 kDa。

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描述

Fc gamma RIIIB/CD16b Protein, a low-affinity receptor for IgG, binds complexed or monomeric IgG. Unlike Fc gamma RIIIA, it cannot mediate antibody-dependent cytotoxicity or phagocytosis. Instead, Fc gamma RIIIB may act as a trap for immune complexes, circulating without activating neutrophils. Existing as a monomer, it interacts with INPP5D/SHIP1, implying its role in intracellular signaling pathways linked to immune responses. Fc gamma RIIIB/CD16b Protein, Human is the recombinant human-derived Fc gamma RIIIB/CD16b protein, expressed by E. coli , with tag free. The total length of Fc gamma RIIIB/CD16b Protein, Human is 176 a.a., with molecular weight of ~22 kDa.

研究背景

Fc gamma RIIIB/CD16b 蛋白充当免疫球蛋白 gamma Fc 区的受体,表现出低亲和力并与复合或聚集的 IgG 以及单体 IgG 结合。与 Fc γ RIIIA 相比,Fc γ RIIIB 缺乏介导抗体依赖性细胞毒性和吞噬作用的能力。相反,它可能充当外周循环免疫复合物的陷阱,而不激活中性粒细胞。该蛋白以单体形式存在,并与 INPP5D/SHIP1 相互作用,表明其参与与免疫反应相关的细胞内信号传导途径。

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

O75015 (M18-G193)

基因 ID
蛋白结构
N-term
CD16b (M18-G193)
Accession # O75015
C-term
同用名
Low affinity immunoglobulin gamma Fc region receptor III-B; FcR-10; FCG3; FCGR3
分子量

Approximately 22 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Fc gamma RIIIB/CD16b Protein, Human
目录号:
HY-P75206
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