1. 重组蛋白
  2. Fc Receptors
  3. FcRn
  4. FCGRT-B2M Heterodimer 蛋白, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His)

FCGRT-B2M Heterodimer 蛋白, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His)

目录号: HY-P77665
产品使用指南

FCGRT 蛋白通过与单体 IgG 结合并促进其从牛奶中的吸收来传递被动免疫。它形成 FcRn-IgG 复合物,通过肠上皮转胞吞,将 IgG 释放到血流或组织液中。该受体还回收 IgG,延长其在循环中的半衰期。从机制上讲,它与酸性内体中的单体 IgG 结合,从而能够回收到细胞表面。FCGRT-B2M 异二聚体还调节白蛋白稳态,由 p51 和 p14 亚基组成。FCGRT-B2M Heterodimer 蛋白, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His) 是重组的蛋白二聚体复合物,包含 FCGRT-B2M 异二聚体蛋白,由 HEK293 表达,带有 C-His 标签。FCGRT-B2M Heterodimer 蛋白, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His),分子量为 35-38 kDa。

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描述

The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His) is a recombinant protein dimer complex containing cynomolgus, Rhesus Macaque-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His), has molecular weight of 35-38 kDa.

研究背景

FCGRT 蛋白是一种细胞表面受体,在将被动体液免疫从母亲转移到新生儿方面发挥着关键作用。它通过与单体免疫球蛋白 γ 的 Fc 区结合并促进其从牛奶中选择性摄取来实现这一点。在肠上皮内,FCGRT-B2M 异二聚体在顶端表面与 IgG 结合,形成 FcRn-IgG 复合物,该复合物在上皮中转胞吞,将 IgG 释放到血流或组织液中。该受体通过回收 IgG 并延长其在循环中的半衰期,在整个生命周期中持续促进有效的体液免疫。从机制上讲,单体 IgG 与内皮细胞和造血细胞酸性内体中的 FCGRT-B2M 结合,使 IgG 能够循环到细胞表面,并释放到循环中。此外,FCGRT-B2M 异二聚体通过与白蛋白(最丰富的循环蛋白)相互作用,在调节白蛋白的稳态中发挥作用。FCGRT-B2M 复合物由两个亚基 p51 和 p14(相当于 β-2-微球蛋白)组成,形成 MHC I 类异二聚体。

种属

Cynomolgus; Rhesus Macaque

表达系统

HEK293

标签

C-His

蛋白编号

Q8SPV9 (A24-S297)&Q8SPW0 (I21-M119)

基因 ID

102128913  [NCBI]

同用名
FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M
分子量

35-38 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

FCGRT-B2M Heterodimer Protein, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
FCGRT-B2M Heterodimer Protein, Cynomolgus/Rhesus Macaque (373a.a, HEK293, His)
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HY-P77665
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