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GSDMC 蛋白, Human (His-SUMO)

目录号: HY-P71649
COA 产品使用指南

GSDMC 蛋白作为成孔蛋白的前体,经过裂解释放 Gasdermin-C。该 N 末端部分与膜结合,形成内径为 10 至 15 nm 的孔并诱导细胞焦亡。GSDMC 蛋白, Human (His-SUMO) 是重组的 GSDMC 蛋白,由 E. coli 表达,带有 N-SUMO, N-6*His 标签。GSDMC 蛋白, Human (His-SUMO) 全长 508 个氨基酸,分子量约为 ~73.7 kDa。

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描述

GSDMC protein serves as the precursor of pore-forming proteins and undergoes cleavage to release Gasdermin-C. This N-terminal moiety binds to the membrane, forming pores with an inner diameter of 10 to 15 nm and inducing pyroptosis. GSDMC Protein, Human (His-SUMO) is the recombinant human-derived GSDMC protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of GSDMC Protein, Human (His-SUMO) is 508 a.a., with molecular weight of ~73.7 kDa.

研究背景

GSDMC 蛋白是成孔蛋白的前体,裂解后,释放的 N 末端部分(称为 Gasdermin-C)与膜结合并形成孔,导致细胞焦亡的诱导。成孔活性涉及 GSDMC 在膜内的均聚,从而形成内径为 10 至 15 纳米的孔。这一过程是由 caspase CASP8 响应死亡信号而裂解 Gasdermin-D 启动的,随后裂解的蛋白质移动到质膜,在质膜上表现出与内叶脂质的强烈结合,最终引发细胞焦亡。

种属

Human

表达系统

E. coli

标签

N-SUMO;N-6*His

蛋白编号

Q9BYG8 (M1-A508)

基因 ID
蛋白结构
N-term
6*His-SUMO
GSDMC (M1-A508)
Accession # Q9BYG8
C-term
同用名
Gasdermin C; Gasdermin-C; GSDMC; Melanoma derived leucine zipper, extra nuclear factor; Melanoma-derived leucine zipper-containing extranuclear factor; MLZE
氨基酸序列

MPSMLERISKNLVKEIGSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEFSLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEFQIVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILGKIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQDEYEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQVHILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMNMLELDSSGHLDGPGGAILKKLQQDSNHAWFNPKDPILYLLEAIMVLSDFQHDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELDNPRSTWDVEAKMPLSALYGTLSLLQQLAEA

分子量

Approximately 73.7 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm sterile filtered 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0 or PBS, 6% Irehalose, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

GSDMC Protein, Human (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
GSDMC Protein, Human (His-SUMO)
目录号:
HY-P71649
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