Hemagglutinin/HA 蛋白, H4N4 (Q0A4G1, HEK293, His)

Hemagglutinin (HA) protein is crucial for virus attachment to host cells, binding to sialic acid receptors and initiating virion internalization through clathrin-dependent or -independent pathways. As a Class I viral fusion protein, HA determines host range and virulence, mediating virus penetration into the cell cytoplasm. Its fusion role between the endocytosed virus and endosomal membranes is vital for infection. Acidic endosomal conditions prompt an irreversible HA2 conformational change, releasing the fusion peptide. Cooperative trimer action forms a fusion pore, highlighting HA's intricate role in viral entry. Hemagglutinin/HA Protein, H4N4 (Q0A4G1, HEK293, His) is the recombinant Virus-derived Hemagglutinin/HA protein, expressed by HEK293, with C-His labeled tag. The total length of Hemagglutinin/HA Protein, H4N4 (Q0A4G1, HEK293, His) is 528 a.a., with molecular weight of ~65 kDa.

血凝素 (HA) 蛋白是病毒颗粒通过与细胞表面含唾液酸的受体结合而附着到宿主细胞的核心。这种相互作用导致病毒粒子通过网格蛋白依赖性内吞作用或网格蛋白和小窝蛋白独立途径内化。HA 在确定宿主范围限制和毒力方面发挥着关键作用，作为 I 类病毒融合蛋白负责病毒渗透到细胞质中。它介导内吞病毒颗粒膜与内体膜之间的融合对于成功感染至关重要。内体中的酸性环境诱导HA2亚基发生不可逆的构象变化，释放融合疏水肽。一个有能力的融合孔的形成需要几个HA三聚体的协同作用，这突显了HA在病毒进入过程中协调的复杂分子过程。

Virus

HEK293

C-His

Q0A4G1 (M1-I528)

/

Approximately 65 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.