1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interferon & Receptors
  4. IFN-γ
  5. IFN-gamma 蛋白, Human (166a.a, CHO)

IFN-gamma 蛋白, Human (166a.a, CHO)

目录号: HY-P73250
产品使用指南

IFN-gamma 蛋白是一种二聚体可溶性细胞因子。通过 JAK-STAT 、mTOR、MAPK 和PI3K/AKT 信号通路发挥抗菌、抗病毒和抗肿瘤作用。IFN-gamma 蛋白, Human (166a.a, CHO) 是重组的 IFN-γ 蛋白,由 CHO 表达,不带标签。IFN-gamma 蛋白, Human (166a.a, CHO) 全长 166 个氨基酸,分子量分别约为 ~21 & 25 kDa。

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该产品已“停产”。 等效替代: HY-P7025A

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描述

IFN-gamma Protein is a dimeric soluble cytokine. It exerts antibacterial, antiviral and antitumor effects through JAK-STAT, mTOR, MAPK and PI3K/AKT signaling pathways. IFN-gamma Protein, Human (166a.a, CHO) is the recombinant human-derived IFN-gamma protein, expressed by CHO , with tag free. The total length of IFN-gamma Protein, Human (166a.a, CHO) is 166 a.a., with molecular weight of ~21 & 25 kDa, respectively.

研究背景

IFN-gamma 是一种二聚体可溶性细胞因子,是II 型干扰素中唯一的成员。IFN-gamma 由免疫细胞T 细胞和NK 细胞产生,通过激活效应免疫细胞和增强抗原呈递,在抗菌、抗病毒和抗肿瘤反应中发挥重要作用。IFN-gamma 通过JAK-STAT 通路与其受体IFNGR1 相互作用后影响基因调控,也可触发mTOR、MAPK 和PI3K/AKT信号通路。IFN-gamma 通过诱导催化蛋白酶体亚基替换为免疫蛋白酶体亚基,在I 类抗原递呈途径中发挥作用。IFN-gamma 通过促进组织蛋白酶B/CTSB、H/CTSH 和L/CTSL 等几个关键分子的表达,上调细胞表面的MHC II 复合物。IFN-gamma 通过影响造血干细胞的发育、静止和分化,参与造血干细胞在发育和稳态条件下的调控。

种属

Human

表达系统

CHO

标签

Tag Free

蛋白编号

P01579 (M1-Q166)

基因 ID
蛋白结构
N-term
IFN-gamma (M1-Q166)
Accession # P01579
C-term
同用名
IFG; IFI; IFNG; IFN-gamma; Immune interferon; Interferon gamma
分子量

Approximately 21&25 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
参考文献

IFN-gamma Protein, Human (166a.a, CHO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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