IL-37 蛋白, Human (166a.a)

IL-37 Protein, a crucial immune regulatory cytokine, suppresses innate inflammatory and immune responses, mitigating excessive inflammation. It signals intracellularly via nuclear translocation with SMAD3 and extracellularly by binding to its receptor, composed of IL18R1 and IL18RAP. IL-37 inhibits pro-inflammatory cytokines, sparing anti-inflammatory ones, and hinders dendritic cell activation. It interacts with SMAD3, binds IL18R1 (with lower affinity than IL18), and forms a complex with TMED10 for secretion. IL-37 Protein, Human (166a.a) is the recombinant human-derived IL-37 protein, expressed by E. coli , with tag free. The total length of IL-37 Protein, Human (166a.a) is 166 a.a., with molecular weight of ~18.7 kDa.

IL-37 蛋白是一种免疫调节细胞因子，作为先天炎症和免疫反应的抑制剂发挥着关键作用，可减轻过度炎症。信号传导通过两种不同的机制发生：细胞内通过 SMAD3 的核转位，以及分泌并与其受体（由 IL18R1 和 IL18RAP 组成）结合后在细胞外发生。 IL-37 抑制或减少促炎细胞因子的产生，包括 IL1A、IL6、CCL12、CSF1、CSF2、CXCL13、IL1B、IL23A 和 IL1RN，同时保留抗炎细胞因子。它还抑制树突状细胞活化。 IL-37 与 SMAD3 相互作用并结合 IL18R1，尽管亲和力低于 IL18，但不充当 IL18 受体拮抗剂。此外，它与货物受体 TMED10 形成复合物，促进从细胞质易位到内质网-高尔基中间室 (ERGIC) 和随后的分泌。

Human

E. coli

Tag Free

Q9NZH6-2 (K27-D192)

27178  [NCBI]

Approximately 18.7 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.