1. 重组蛋白
  2. Receptor Proteins
  3. Leukocyte Immunoglobin-like Receptors
  4. Leukocyte Ig-Like Receptor B4
  5. LILRB4/CD85k/ILT3 蛋白, Human (Domain1&2, HEK293, His)

LILRB4/CD85k/ILT3 蛋白, Human (Domain1&2, HEK293, His)

目录号: HY-P77741
产品使用指南

LILRB4/CD85k/ILT3蛋白是关键的抑制性受体,在免疫调节和耐受中发挥关键作用。作为 FN1、载脂蛋白 APOE 和 ALCAM/CD166 的受体,它抑制受体介导的磷酸化、细胞内钙动员和 FCGR1A/CD64 介导的单核细胞活化,从而减少 TNF 的产生。LILRB4/CD85k/ILT3 蛋白, Human (Domain1&2, HEK293, His) 是重组的 LILRB4/CD85k/ILT3 蛋白,由 HEK293 表达,带有 C-His 标签。LILRB4/CD85k/ILT3 蛋白, Human (Domain1&2, HEK293, His) 全长 192 个氨基酸,分子量为 23-25 kDa。

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描述

The LILRB4/CD85k/ILT3 protein is a key inhibitory receptor that plays a key role in immune regulation and tolerance. As a receptor for FN1, apolipoprotein APOE, and ALCAM/CD166, it inhibits receptor-mediated phosphorylation, intracellular calcium mobilization, and FCGR1A/CD64-mediated monocyte activation, thereby reducing TNF production. LILRB4/CD85k/ILT3 Protein, Human (Domain1&2, HEK293, His) is the recombinant human-derived LILRB4/CD85k/ILT3 protein, expressed by HEK293 , with C-His labeled tag. The total length of LILRB4/CD85k/ILT3 Protein, Human (Domain1&2, HEK293, His) is 192 a.a., with molecular weight of 23-25 kDa.

研究背景

LILRB4/CD85k/ILT3 是一种抑制性受体,在免疫调节和免疫耐受的建立中发挥着关键作用。该蛋白作为 FN1、载脂蛋白 APOE 和 ALCAM/CD166 的受体,参与多种细胞过程。它抑制受体介导的细胞蛋白磷酸化和细胞内钙离子的动员,并进一步下调 FCGR1A/CD64 介导的单核细胞活化,导致 TNF 产生减少。此外,LILRB4/ILT3 会阻碍 T 细胞增殖,诱导无反应性,抑制产生 IFNG 的 CD8+ 细胞毒性 T 细胞的分化,并促进 CD8+ T 抑制细胞的生成。它诱导树突状细胞上 CD86 上调,并干扰 TNFRSF5 信号传导和 NF-kappa-B 上调。抑制作用至少部分是通过与 FN1 和磷酸酶 PTPN6 的相互作用介导的。

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

Q8NHJ6 (P27-S218)

基因 ID
蛋白结构
N-term
LILRB4 (P27-S218)
Accession # Q8NHJ6
His
C-term
同用名
HM18; ILT3; ILT-3; LILRB4; LIR5; CD85K
分子量

23-25 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

LILRB4/CD85k/ILT3 Protein, Human (Domain1&2, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
LILRB4/CD85k/ILT3 Protein, Human (Domain1&2, HEK293, His)
目录号:
HY-P77741
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