1. 重组蛋白
  2. Complement System
  3. Mannose-binding Protein
  4. Mannose-binding Protein C
  5. MBL2/COLEC1 蛋白, Mouse (HEK293, Fc)

MBL2/COLEC1 蛋白, Mouse (HEK293, Fc)

目录号: HY-P76487
产品使用指南

MBL2/COLEC1 蛋白是一种钙依赖性凝集素,可与微生物上的甘露糖、岩藻糖和 N-乙酰氨基葡萄糖结合,激活凝集素补体途径。它还与晚期凋亡细胞、凋亡泡和坏死细胞结合,帮助巨噬细胞摄取它们。 MBL2 与同源三聚体形成寡聚复合物,并与 MASP1、MASP2、MEP1A 和 MEP1B 相互作用。它在免疫防御、针对微生物入侵者和清除凋亡和坏死细胞方面发挥着至关重要的作用。MBL2/COLEC1 蛋白, Mouse (HEK293, Fc) 是重组的 MBL2/COLEC1 蛋白,由 HEK293 表达,带有 N-mFc 标签。MBL2/COLEC1 蛋白, Mouse (HEK293, Fc) 全长 226 个氨基酸,分子量约为 ~50.6 KDa。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

MBL2/COLEC1 Protein, a calcium-dependent lectin, binds to mannose, fucose, and N-acetylglucosamine on microorganisms, activating the lectin complement pathway. It also binds to late apoptotic cells, apoptotic blebs, and necrotic cells, aiding their uptake by macrophages. MBL2 forms an oligomeric complex with homotrimers and interacts with MASP1, MASP2, MEP1A, and MEP1B. It plays a crucial role in immune defense, targeting microbial invaders and clearing apoptotic and necrotic cells. MBL2/COLEC1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived MBL2/COLEC1 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of MBL2/COLEC1 Protein, Mouse (HEK293, Fc) is 226 a.a., with molecular weight of ~50.6 KDa.

研究背景

MBL2(甘露糖结合凝集素 2),也称为 COLEC1,是一种钙依赖性凝集素,在先天免疫防御中发挥着至关重要的作用。该蛋白与多种微生物上的甘露糖、岩藻糖和 N-乙酰氨基葡萄糖结合,从而激活凝集素补体途径。此外,MBL2 与晚期凋亡细胞、凋亡泡和坏死细胞结合,促进巨噬细胞摄取它们。该蛋白形成由三个或更多同源三聚体组成的寡聚复合物,并与 MASP1 和 MASP2 相互作用。此外,MBL2 与 MEP1A 和 MEP1B 相互作用,可能抑制它们的催化活性。总体而言,MBL2 在免疫反应中发挥着关键作用,识别和靶向微生物入侵者,同时有助于清除凋亡和坏死细胞。

种属

Mouse

表达系统

HEK293

标签

N-mFc

蛋白编号

P41317 (E19-D244)

基因 ID

17195  [NCBI]

蛋白结构
N-term
mFc
MBL2 (E19-D244)
Accession # P41317
C-term
同用名
Mannose-binding protein C; MBP-C; RARF/P28A; COLEC1; Mbl2
分子量

Approximately 50.6 kDa.

纯度

Greater than 90% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

MBL2/COLEC1 Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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