1. 重组蛋白
  2. Cytokines and Growth Factors
  3. EGF Superfamily
  4. Neuregulins
  5. Neuregulin-1 (NRG1)
  6. NRG1-beta 1 蛋白, Human (65a.a)

NRG1-beta 1 蛋白, Human (65a.a)

目录号: HY-P71171
产品使用指南

NRG1-α 蛋白作为 ERBB3 和 ERBB4 酪氨酸激酶受体的直接配体,同时招募 ERBB1 和 ERBB2 辅助受体,从而诱导配体刺激的酪氨酸磷酸化和 ERBB 受体的激活。其多种亚型的不同功能包括诱导各种细胞类型的生长和分化,包括上皮细胞、神经胶质细胞、神经元细胞和骨骼肌细胞。 NRG1-α 还参与神经肌肉接头形成过程中乙酰胆碱受体的表达、刺激乳腺小叶肺泡出芽和产奶以及诱导乳腺肿瘤细胞分化。此外,它还能刺激雪旺细胞增殖,并在心肌发育中发挥作用,特别是有助于发育中心脏的小梁形成。同工型 10 与运动和感觉神经元发育有关。 NRG1-alpha 与 ERBB4 和 ERBB3 结合,作为整合素的配体,并与整合素和 ERBB3 形成三元复合物,这是 NRG1-ERBB 信号转导中的关键步骤。它诱导 MAPK3/ERK1、MAPK1/ERK2 和 AKT1 的磷酸化和激活。此外,NRG1-alpha 参与配体依赖性 ERBB4 内吞作用,这对于神经元中这些激酶的激活至关重要,并与 LIMK1 的 LIM 结构域区域相互作用。它还与 ERBB3 和整合素 ITGAV:ITGB3 或 ITGA6:ITGB4 形成三元复合物,并与 NRDC 和 BACE1 相互作用。NRG1-beta 1 蛋白, Human (65a.a) 是重组的 NRG1-β 1 蛋白,由 E. coli 表达,不带标签。NRG1-beta 1 蛋白, Human (65a.a) 全长 65 个氨基酸,分子量约为 ~9 kDa。

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描述

NRG1-alpha protein acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concurrently recruiting ERBB1 and ERBB2 coreceptors, thereby inducing ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The diverse functions of its multiple isoforms encompass the induction of growth and differentiation in various cell types, including epithelial, glial, neuronal, and skeletal muscle cells. NRG1-alpha is also involved in the expression of acetylcholine receptors during neuromuscular junction formation, the stimulation of lobuloalveolar budding and milk production in the mammary gland, and the induction of differentiation in mammary tumor cells. Furthermore, it stimulates Schwann cell proliferation and plays a role in myocardial development, specifically contributing to the trabeculation of the developing heart. Isoform 10 is implicated in motor and sensory neuron development. NRG1-alpha binds to ERBB4 and ERBB3, acting as a ligand for integrins and forming a ternary complex with integrins and ERBB3, a crucial step in NRG1-ERBB signaling. It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2, and AKT1. Additionally, NRG1-alpha participates in ligand-dependent ERBB4 endocytosis, essential for the activation of these kinases in neurons, and interacts with the LIM domain region of LIMK1. It also forms a ternary complex with ERBB3 and integrins ITGAV:ITGB3 or ITGA6:ITGB4 and interacts with NRDC and BACE1. NRG1-beta 1 Protein, Human (65a.a) is the recombinant human-derived NRG1-beta 1 protein, expressed by E. coli , with tag free. The total length of NRG1-beta 1 Protein, Human (65a.a) is 65 a.a., with molecular weight of ~9 kDa.

研究背景

NRG1-α 蛋白作为 ERBB3 和 ERBB4 酪氨酸激酶受体的直接配体,同时招募 ERBB1 和 ERBB2 辅助受体,从而诱导配体刺激的酪氨酸磷酸化和 ERBB 受体的激活。其多种亚型的不同功能包括诱导各种细胞类型的生长和分化,包括上皮细胞、神经胶质细胞、神经元细胞和骨骼肌细胞。 NRG1-α 还参与神经肌肉接头形成过程中乙酰胆碱受体的表达、刺激乳腺小叶肺泡出芽和产奶以及诱导乳腺肿瘤细胞分化。此外,它还能刺激雪旺细胞增殖,并在心肌发育中发挥作用,特别是有助于发育中心脏的小梁形成。同工型 10 与运动和感觉神经元发育有关。 NRG1-alpha 与 ERBB4 和 ERBB3 结合,作为整合素的配体,并与整合素和 ERBB3 形成三元复合物,这是 NRG1-ERBB 信号转导中的关键步骤。它诱导 MAPK3/ERK1、MAPK1/ERK2 和 AKT1 的磷酸化和激活。此外,NRG1-alpha 参与配体依赖性 ERBB4 内吞作用,这对于神经元中这些激酶的激活至关重要,并与 LIMK1 的 LIM 结构域区域相互作用。它还与 ERBB3 和整合素 ITGAV:ITGB3 或 ITGA6:ITGB4 形成三元复合物,并与 NRDC 和 BACE1 相互作用。

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

Q02297-6 (S177-E241)

基因 ID

3084  [NCBI]

蛋白结构
N-term
NRG1-beta 1 (S177-E241)
Accession # Q02297-6
C-term
同用名
Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1; EGF; NRG1; GGF; HGL; HRGA; NDF; SMDF;
氨基酸序列

SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAE

分子量

Approximately 9 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

NRG1-beta 1 Protein, Human (65a.a) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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