1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins
  4. PD-1
  5. PD-1 蛋白, Human (167a.a, HEK293, His)

PD-1 蛋白, Human (167a.a, HEK293, His)

目录号: HY-P73346
产品使用指南

PD-1蛋白是T细胞上的抑制性受体,通过与CD274/PDCD1L1和CD273/PDCD1LG2结合来维持免疫耐受。它通过与 CD3-TCR 结合并招募 PTPN11/SHP-2 使关键信号分子去磷酸化来阻止 T 细胞活化。PD-1 蛋白, Human (167a.a, HEK293, His) 是重组的 PD-1 蛋白,由 HEK293 表达,带有 C-His 标签。PD-1 蛋白, Human (167a.a, HEK293, His) 全长 143 个氨基酸,分子量约为 ~41.1 kDa。

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重组蛋白定制服务

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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该产品已“停产”。 等效替代: HY-P7396

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描述

PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (167a.a, HEK293, His) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of PD-1 Protein, Human (167a.a, HEK293, His) is 143 a.a., with molecular weight of ~41.1 kDa.

研究背景

PD-1蛋白作为抗原激活T细胞的抑制性受体,在诱导和维持自身免疫耐受中发挥着至关重要的作用。PD-1 与其配体 CD274/PDCD1L1 和 CD273/PDCD1LG2 结合后,会传递抑制信号并与免疫突触中的 CD3-TCR 结合,直接阻碍 T 细胞激活。这种抑制作用通过招募 PTPN11/SHP-2 进一步执行,导致关键 TCR 近端信号分子去磷酸化。PD-1 与 CD274/PDCD1L1 的相互作用会被肿瘤利用来减弱抗肿瘤免疫力,从而抑制细胞毒性 T 淋巴细胞 (CTL) 效应器功能。阻断 PD-1 介导的通路有望逆转耗尽的 T 细胞表型并使抗肿瘤反应正常化,从而为癌症免疫治疗提供了理论依据。

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

Q15116 (L25-Q167)

基因 ID
蛋白结构
N-term
PD-1 (L25-Q167)
Accession # Q15116
His
C-term
同用名
CD279; hPD-1; PDCD1; Programmed cell death 1; SLEB2
分子量

Approximately 41.1 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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