1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins
  4. PD-L1 PD-L1/CD274
  5. PD-L1 蛋白, Mouse (239a.a, HEK293, Fc)

PD-L1 蛋白, Mouse (239a.a, HEK293, Fc)

目录号: HY-P73363
COA 产品使用指南

PD-L1 蛋白作为抑制性受体 PDCD1/PD-1 的配体,对于维持免疫耐受至关重要。这种相互作用调节 T 细胞激活,限制效应反应,并可能刺激产生 IL10 的 T 细胞亚群。PD-L1 蛋白, Mouse (239a.a, HEK293, Fc) 是重组的 PD-L1 蛋白,由 HEK293 表达,带有 C-hFc 标签。PD-L1 蛋白, Mouse (239a.a, HEK293, Fc) 全长 239 个氨基酸,分子量约为 ~51.6 kDa。

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规格 价格 是否有货 数量
100 μg ¥4200 In-stock
> 100 μg   询价  

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描述

PD-L1 protein serves as a ligand for the inhibitory receptor PDCD1/PD-1 and is critical for maintaining immune tolerance. This interaction modulates T cell activation, limits effector responses and may stimulate IL10-producing T cell subsets. PD-L1 Protein, Mouse (239a.a, HEK293, Fc) is the recombinant mouse-derived PD-L1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-L1 Protein, Mouse (239a.a, HEK293, Fc) is 239 a.a., with molecular weight of ~51.6 kDa.

研究背景

PD-L1 蛋白作为抑制性受体 PDCD1/PD-1 的配体,在维持自身免疫耐受方面发挥着至关重要的作用。这种相互作用调节 T 细胞的激活阈值,限制其效应反应,并可能刺激产生白细胞介素 10 (IL10) 的 T 细胞亚群。然而,肿瘤利用PDCD1介导的抑制途径来减弱抗肿瘤免疫力并逃避免疫系统的破坏,从而促进肿瘤存活。PD-L1 和 PDCD1/PD-1 之间的相互作用会抑制细胞毒性 T 淋巴细胞 (CTL) 的功能,但阻断该通路可以逆转耗尽的 T 细胞表型并使抗肿瘤反应正常化,为癌症免疫治疗提供了一种有前景的策略。

种属

Mouse

表达系统

HEK293

标签

C-hFc

蛋白编号

Q9EP73 (M1-H239)

基因 ID
蛋白结构
N-term
PD-L1 (M1-H239)
Accession # Q9EP73
hFc
C-term
同用名
Programmed cell death 1 ligand 1; PD-L1; B7-H1; CD274; PDL1
分子量

Approximately 51.6 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
PD-L1 Protein, Mouse (239a.a, HEK293, Fc)
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HY-P73363
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