1. 重组蛋白
  2. Cytokines and Growth Factors CD Antigens
  3. TNF Superfamily T Cell CD Proteins Macrophage CD Proteins
  4. TNF Superfamily Ligands RANKL/CD254
  5. RANKL
  6. RANK L/TNFSF11 蛋白, Mouse (HEK293, His)

RANK L/TNFSF11 蛋白, Mouse (HEK293, His)

目录号: HY-P7425A
COA 产品使用指南

RANK L/TNFSF11 蛋白, Mouse (HEK293, His)是来源于 CHO 的 TNF 相关的活化诱导细胞因子。人源和鼠源 RANK L/TNFSF11 的同源性约为 82%。RANK L/TNFSF11 蛋白, His (CHO-expressed) 诱导 JNK 的激活,增强 T 细胞生长和树突细胞功能,诱导破骨细胞生成和淋巴结器官生成。

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规格 价格 是否有货 数量
10 μg ¥3200 In-stock
50 μg ¥9800 In-stock
100 μg   询价  
250 μg   询价  

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描述

RANK L/TNFSF11 Protein, Mouse (HEK293, His) is a TNF-related activation-induced cytokine produced in CHO. Mouse and human RANK Ligand share 85% amino acid identity. RANK L/TNFSF11 Protein, Mouse (CHO, His) induces the activation of the c-jun N terminal kinase, enhances T cell growth and dendritic cell function, induces osteoclastogenesis, and lymph node organogenesis.

研究背景

Receptor activator of NF-κB ligand (RANKL), its cellular receptor, receptor activator of NF-κB (RANK), and the decoy receptor osteoprotegerin (OPG) constitute a novel cytokine system. RANKL produced by osteoblastic lineage cells and activated T lymphocytes is the essential factor for osteoclast formation, fusion, activation, and survival, thus resulting in bone resorption and bone loss. RANKL activates its specific receptor, RANK located on osteoclasts and dendritic cells, and its signaling cascade involves stimulation of the c-jun, NF-κB, and serine/threonine kinase PKB/Akt pathways[1].

生物活性

Immobilized human OPG-Fc at 2μg/mL (100 μL/well) can bind mouse RANKL-His and the ED50 is 2.44ug/mL .

种属

Mouse

表达系统

HEK293

标签

Tag Free

蛋白编号

O35235 (R72-D316)

基因 ID

21943  [NCBI]

同用名
rMuRANK L/TNFSF11, His; TRANCE; CD254
氨基酸序列

HHHHHHRAQMDPNRISEDSTHCFYRILRLHENADLQDSTLESEDTLPDSCRRMKQAFQGAVQKELQHIVGPQRFSGAPAMMEGSWLDVAQRGKPEAQPFAHLTINAASIPSGSHKVTLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSVPTDYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAFKVQDID

分子量

Approximately 28.3 kDa

性状

Lyophilized powder.

组分

Lyophilized after extensive dialysis against PBS, pH 7.4.

内毒素含量

<1.0 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献
  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
RANK L/TNFSF11 Protein, Mouse (HEK293, His)
目录号:
HY-P7425A
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