SOST 蛋白, Human (HEK293, His-Avi)

SOST protein acts as a potent inhibitor of bone growth by effectively suppressing Wnt signaling and subsequent bone formation. Through interactions with key Wnt pathway components, including LRP4, LRP5, and LRP6, SOST exerts inhibitory effects. Its interaction with LRP4, mediated by the extracellular domain, suppresses Wnt signaling, while interactions with LRP5, specifically through the first two YWTD-EGF repeat domains, contribute to Wnt-mediated signaling inhibition. These interactions emphasize SOST's crucial role in regulating bone development and maintaining bone homeostasis. SOST Protein, Human (HEK293, His-Avi) is the recombinant human-derived SOST protein, expressed by HEK293, with N-His, N-Avi labeled tag. The total length of SOST Protein, Human (HEK293, His-Avi) is 190 a.a., with molecular weight of 28-40 kDa.

SOST 蛋白通过有效抑制 Wnt 信号传导和随后的骨形成，充当骨生长的有效负调节因子。SOST 通过与 Wnt 通路的关键成分（包括 LRP4、LRP5 和 LRP6）相互作用，发挥其抑制作用。值得注意的是，它与 LRP4 的相互作用（通过胞外结构域介导）有助于抑制 Wnt 信号传导，而与 LRP5 的相互作用（特别是通过前两个 YWTD-EGF 重复结构域）有助于抑制 Wnt 介导的信号传导。这些分子相互作用强调了 SOST 在调节控制骨骼发育的复杂信号级联中的关键作用，提供维持骨骼稳态的重要调节机制。

Human

HEK293

N-His;N-Avi

Q9BQB4 (Q24-Y213)

50964  [NCBI]

28-40 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.