2. 重组蛋白
  3. Enzymes & Regulators
  4. Transferases (EC 2)
  5. TGM2/Transglutaminase 2 蛋白, Mouse (HEK293, His)

TGM2/Transglutaminase 2 蛋白, Mouse (HEK293, His)

目录号: HY-P71132
COA 产品使用指南

TGM2/转谷氨酰胺酶 2 蛋白是一种钙依赖性酰基转移酶，参与骨发育、血管生成、伤口愈合和细胞凋亡。TGM2 还参与神经传递独立的作用，并在 α-1 肾上腺素受体介导的途径中充当信号转导器。TGM2/Transglutaminase 2 蛋白, Mouse (HEK293, His) 是重组的 TGM2/转谷氨酰胺酶 2 蛋白，由 HEK293 表达，带有 C-6*His 标签。TGM2/Transglutaminase 2 蛋白, Mouse (HEK293, His) 全长 685 个氨基酸，分子量为 70-90 kDa。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 μg ￥1800 In-stock
50 μg ￥5000 In-stock
100 μg   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

The TGM2/transglutaminase 2 protein is a calcium-dependent acyltransferase involved in bone development, angiogenesis, wound healing, and apoptosis. TGM2 is also involved in neurotransmission-independent actions and serves as a signal transducer in α-1 adrenergic receptor-mediated pathways. TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) is 685 a.a., with molecular weight of 70-90 kDa.
研究背景

TGM2/转谷氨酰胺酶 2 蛋白是一种钙依赖性酰基转移酶，催化肽结合的谷氨酰胺和各种伯胺之间形成共价键，导致蛋白质交联或胺化。TGM2 充当蛋白质-谷氨酰胺 γ-谷氨酰转移酶，参与多种生物过程，如骨骼发育、血管生成、伤口愈合、细胞分化、染色质修饰和细胞凋亡。它介导蛋白质的交联，包括 ACO2、HSPB6、FN1、HMGB1、RAP1GDS1、SLC25A4/ANT1、SPP1 和 WDR54。在生理条件下，GTP 会抑制蛋白质交联活性，而在应对各种应激时，Ca(2+) 会缓解这种抑制。除了通过促进细胞骨架蛋白交联和介导细胞外基质支架的形成在细胞凋亡中发挥作用外，TGM2 还可以使用单胺底物催化多种蛋白质翻译后修饰。它通过介导组蛋白 H3 的血清素化和多巴胺化在染色质组织中发挥至关重要的作用，有助于腹侧被盖区 (VTA) 神经元的神经传递独立功能。此外，TGM2 在 α1 肾上腺素受体介导的磷脂酶 C-δ (PLCD) 活性刺激中充当信号转导器，突出显示其参与除酰基转移酶活性之外的信号通路。
生物活性

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
种属

Mouse
表达系统

HEK293
标签

C-6*His
蛋白编号

P21981 (A2-A686)
基因 ID

21817  [NCBI]
蛋白结构
N-term
TGM2 (A2-A686)
Accession # P21981
6*His
C-term
同用名
Protein-glutamine gamma-glutamyltransferase 2; Tgm2; Tissue transglutaminase; Transglutaminase C; TGase-2
氨基酸序列

AEELLLERCDLEIQANGRDHHTADLCQEKLVLRRGQRFRLTLYFEGRGYEASVDSLTFGAVTGPDPSEEAGTKARFSLSDNVEEGSWSASVLDQQDNVLSLQLCTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLYNAWCPADDVYLDSEEERREYVLTQQGFIYQGSVKFIKSVPWNFGQFEDGILDTCLMLLDMNPKFLKNRSRDCSRRSSPIYVGRVVSAMVNCNDDQGVLLGRWDNNYGDGISPMAWIGSVDILRRWKEHGCQQVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGELESNKSEMIWNFHCWVESWMTRPDLQPGYEGWQAIDPTPQEKSEGTYCCGPVSVRAIKEGDLSTKYDAPFVFAEVNADVVDWIRQEDGSVLKSINRSLVVGQKISTKSVGRDDREDITHTYKYPEGSPEEREVFTKANHLNKLAEKEETGVAMRIRVGDSMSMGNDFDVFAHIGNDTSETRECRLLLCARTVSYNGVLGPECGTEDINLTLDPYSENSIPLRILYEKYSGCLTESNLIKVRGLLIEPAANSYLLAERDLYLENPEIKIRVLGEPKQNRKLVAEVSLKNPLSDPLYDCIFTVEGAGLTKEQKSVEVSDPVPAGDLVKARVDLFPTDIGLHKLVVNFQCDKLKSVKGYRNVIIGPA

分子量

70-90 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
性状

溶液.
组分

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 20% Glycerol, pH 7.5.
内毒素含量

<1 EU/μg, determined by LAL method.
保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
运输条件

Shipping with dry ice.
文件资料

COA (209 KB)

产品使用指南 (1213 KB)

TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His)
目录号：
HY-P71132
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z