VEGF-CC 蛋白, Mouse/Rat (HEK293, Fc)

VEGF-CC protein stimulates cell proliferation, migration, and vascular permeability, which are critical for angiogenesis and endothelial cell dynamics. It plays a crucial role in the development of the venous and lymphatic vasculature during embryogenesis and in the maintenance of adult lymphatic endothelium. VEGF-CC Protein, Mouse/Rat (HEK293, Fc) is the recombinant rat, mouse-derived VEGF-CC protein, expressed by HEK293 , with N-hFc labeled tag. The total length of VEGF-CC Protein, Mouse/Rat (HEK293, Fc) is 116 a.a., with molecular weight of ~44 & 34 kDa, respectively.

VEGF-CC 是一种在血管生成和内皮细胞动力学中至关重要的生长因子，对细胞增殖和迁移发挥刺激作用，同时也影响血管的通透性。它在血管生成中发挥着至关重要的作用，特别是在胚胎发生过程中静脉和淋巴管系统的发育中。此外，VEGF-CC 有助于维持成人分化的淋巴内皮。该蛋白结合并激活 KDR/VEGFR2 和 FLT4/VEGFR3 受体，协调血管发育和稳态的重要信号通路。在结构上，VEGF-CC 形成具有非共价和反向平行排列的同二聚体。它与 FLT4/VEGFR3 的相互作用对于 FLT4/VEGFR3 同二聚化和随后的激活至关重要，突出了其在血管过程中的复杂调节作用。

1.Immobilized mouse FLT4-His at 10 μg/mL (100 μL/well) can bind mouse/rat Fc-VEGFC and the EC₅₀ is 0.41-0.95 μg/mL.
2.Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC) and the ED₅₀ is typically 70-300 ng/mL

Rat; Mouse

HEK293

N-hFc

P97953 (A108-R223)/O35757(A108-R223)

22341  [NCBI]/114111

Approximately 44&34 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.