2. Apoptosis
  3. MDM-2/p53
  4. MDM2/4-p53-IN-3

MDM2/4-p53-IN-3 是一种 MDM2/4-p53 蛋白质-蛋白质相互作用 (PPI) 抑制剂 (IC50s: 18.5 nM, MDM2-p53; 14.8 nM, MDM4-p53)。MDM2/4-p53-IN-3 可用于癌症研究，如结肠癌。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

MDM2/4-p53-IN-3 Chemical Structure

MDM2/4-p53-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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MDM2/4-p53-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MDM2/4-p53-IN-3 is a MDM2/4-p53 protein-protein interactions (PPIs) inhibitor (IC50s: 18.5 nM for MDM2-p53, 14.8 nM for MDM4-p53). MDM2/4-p53-IN-3 can be used in the research of cancers, such as colon cancer[1].

IC50 & Target

MDM2/4-p53 protein-protein interactions (PPIs)[1]
体外研究
(In Vitro)

MDM2/4-p53-IN-3 (Compound 2a, 1-100 μM, 48 h) inhibits cell proliferation[1].
MDM2/4-p53-IN-3 dissociates p53-MDMs complexes (immunoenzymatic assays) with IC50 values of 18.5 nM (MDM2-p53) and 14.8 nM (MDM4-p53)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2/4-p53-IN-3 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HCT116, SJSA-1, LNCaP, MCF-7
Concentration: 1-100 μM
Incubation Time: 48 h (HCT116), 72 h (MCF-7), 96 h (SJSA-1, LNCaP)
Result: Inhibited cell proliferation with IC50 values of 23.6 μM (HCT116), 12.6 μM (SJSA-1), 13.1 μM (LNCaP), 14.3 μM (MCF-7).
分子量

504.38

Formula

C25H24Cl2FN3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MDM2/4-p53-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2/4-p53-IN-3MDM-2/p53CancerHCT116p53-MDM PPIcolon cancercarcinogenesisInhibitorinhibitorinhibit

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