1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Calcium Channel
    Mitochondrial Metabolism
  3. Ru360


目录号: HY-122898 纯度: ≥99.0%

Ru360,一种氧桥联的双核钌胺络合物,是一种选择性的线粒体钙摄取 (mitochondrial calcium uptake) 抑制剂。Ru360 有效抑制 Ca2+ 吸收到线粒体中,IC50 为 0.184 nM。Ru360 以高亲和力 (Kd 为 0.34 nM) 与线粒体结合。Ru360 具有抗心律失常和心脏保护作用。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Ru360 Chemical Structure

Ru360 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内


3.  试用装只面向终端客户

Size Price Stock
100 μg ¥3250 Ask For Quote & Lead Time
500 μg ¥8200 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献


Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2].

IC50 & Target

IC50: 0.184 nM (Ca2+ uptake into mitochondria)[2]
Kd: 0.34 nM (Mitochondria)[2]

In Vitro

Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial cells and accumulated in the cytosol in a biphasic manner[1].
During pelleting hypoxia, Ru360 (10 µM) significantly improves cell viability in wild type cardiomyocytes[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ru360 (15-50 nmol/kg) treatment abolishes the incidence of arrhythmias and haemodynamic dysfunction elicited by reperfusion in a whole rat model. Ru360 administration partially inhibits calcium uptake, preventing mitochondria from depolarization by the opening of the mitochondrial permeability transition pore (mPTP)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight



C₂H₂₆Cl₃N₈O₅Ru₂ ₃-




Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 0.5 mg/mL (0.91 mM; Need ultrasonic and warming)


Purity: ≥99.0%

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


Ru360Ru 360Ru-360Calcium ChannelMitochondrial MetabolismCa2+ channelsCa channelsMitochondrialcalciumuptakerutheniumredantiarrhythmiccardioprotectiveoxygen-bridgeddinuclearInhibitorinhibitorinhibit


Your information is safe with us. * Required Fields.



* 需求量:

* 客户姓名:


* Email:

* 电话:


* 公司或机构名称:


Bulk Inquiry

Inquiry Information