1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Calcium Channel
    Mitochondrial Metabolism
  3. Ru360

Ru360 

目录号: HY-122898 纯度: ≥99.0%
产品使用指南

Ru360,一种氧桥联的双核钌胺络合物,是一种选择性的线粒体钙摄取 (mitochondrial calcium uptake) 抑制剂。Ru360 有效抑制 Ca2+ 吸收到线粒体中,IC50 为 0.184 nM。Ru360 以高亲和力 (Kd 为 0.34 nM) 与线粒体结合。Ru360 具有抗心律失常和心脏保护作用。

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Ru360 Chemical Structure

Ru360 Chemical Structure

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100 μg ¥3250 Ask For Quote & Lead Time
500 μg ¥8200 Ask For Quote & Lead Time

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Description

Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2].

IC50 & Target

IC50: 0.184 nM (Ca2+ uptake into mitochondria)[2]
Kd: 0.34 nM (Mitochondria)[2]

In Vitro

Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial cells and accumulated in the cytosol in a biphasic manner[1].
During pelleting hypoxia, Ru360 (10 µM) significantly improves cell viability in wild type cardiomyocytes[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ru360 (15-50 nmol/kg) treatment abolishes the incidence of arrhythmias and haemodynamic dysfunction elicited by reperfusion in a whole rat model. Ru360 administration partially inhibits calcium uptake, preventing mitochondria from depolarization by the opening of the mitochondrial permeability transition pore (mPTP)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

550.78

Formula

C₂H₂₆Cl₃N₈O₅Ru₂ ₃-

SMILES

[NH3][Ru]([NH3])([NH3])([NH3])(O[Ru]([NH3])([NH3])([NH3])([NH3])OC=O)OC=O.[Cl-].[Cl-].[Cl-].[3+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 0.5 mg/mL (0.91 mM; Need ultrasonic and warming)

References

Purity: ≥99.0%

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Keywords:

Ru360Ru 360Ru-360Calcium ChannelMitochondrial MetabolismCa2+ channelsCa channelsMitochondrialcalciumuptakerutheniumredantiarrhythmiccardioprotectiveoxygen-bridgeddinuclearInhibitorinhibitorinhibit

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产品名称:
Ru360
目录号:
HY-122898
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