2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Cannabinoid Receptor NO Synthase
  4. Zevaquenabant

Zevaquenabant  (Synonyms: (S)-MRI-1867)

目录号: HY-141411A
产品使用指南

摩尔计算器

Zevaquenabant ((S)-MRI-1867) 是一种受外周限制的，具有口服生物利用的大麻素 CB1 受体和诱导型 NOS (iNOS) 双拮抗剂。Zevaquenabant 改善肥胖引起的慢性肾脏疾病 (CKD)。

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Zevaquenabant Chemical Structure

Zevaquenabant Chemical Structure

CAS No. : 1998760-00-1

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Other Forms of Zevaquenabant:

Zevaquenabant 相关抗体

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual cannabinoid CB1 receptor and inducible NOS antagonist. Zevaquenabant ameliorates obesity-induced chronic kidney disease (CKD)[1].

IC50 & Target[1]

CB1

 

体外研究
(In Vitro)

Zevaquenabant can simultaneously inhibit CB1 receptors and inducible NOS in peripheral organs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Zevaquenabant 相关抗体:
体内研究
(In Vivo)

Zevaquenabant (3 mg/kg; p.o.; for 28 days) improves renal morphological and functional parameters in diet-induced obese mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male C57Bl/6J mice (diet-induced obesity)[1]
Dosage: 3 mg/kg
Administration: P.o.; for 28 days
Result: Improved kidney morphology and function in diet-induced obese mice.
分子量

547.98

Formula

C25H21ClF3N5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Zevaquenabant 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zevaquenabant1998760-00-1(S)-MRI-1867Cannabinoid ReceptorNO SynthaseNitric oxide synthasesNOSperipherallyoralobesitychronickidneyCKDInhibitorinhibitorinhibit

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