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Targets Recommended: Isocitrate Dehydrogenase (IDH)

Results for "Ag881 idh 抑制剂" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-104042
    Vorasidenib

    Ag-881

    Isocitrate Dehydrogenase (IDH) Cancer
    Vorasidenib (AG-881) 是一种可口服的、脑渗透的第二代突变体异柠檬酸脱氢酶 1 和 2 (mIDH1/2) 双重抑制剂。Vorasidenib (AG-881) 以纳摩尔抑制 D-2-HG,对 IDH1 R132C、IDH1 R132G、IDH1 R132H、IDH1 R132S 的 IC50 值为 0.04~22 nM,对 IDH2 R140Q 值为 7~14 nM,对 IDH2 R172K 的值为 130 nM。