2. PI3K/Akt/mTOR
  3. Akt
  4. SM1-71-R

SM1-71-R 是 SM1-71 (HY-136848) 的可逆类似物。SM1-71-R 缺乏丙烯酰胺弹头，因此无法与激酶形成共价键。SM1-71-R 可用作 SM1-71 的对照化合物。

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SM1-71-R

SM1-71-R Chemical Structure

CAS No. : 2088180-03-2

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规格 价格 是否有货 数量
5 mg ￥1720
In-stock
10 mg ￥2864
In-stock
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SM1-71-R 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SM1-71-R is a reversible analog o SM1-71 (HY-136848). SM1-71-R lacks the acrylamide warhead and therefore cannot form a covalent bond with the kinase. SM1-71-R can be used as a control compound for SM1-71[1].

体外研究
(In Vitro)

SM1-71-R (1 μM；2 小时) 可抑制 H23-KRASG12C 细胞中 p-AKTS473 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SM1-71-R 相关抗体:

Western Blot Analysis[1]

Cell Line: H23-KRASG12C cells
Concentration: 1 μM
Incubation Time: 2 h
Result: Resulted in inhibition of phosphorylation of only p-AKTS473, did not inhibit phosphorylation on p-ERK1/2T202/Y204 and p-MEK1/2S217/S221 levels.
分子量

465.98

Formula

C24H28ClN7O
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

SM1-71-R 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SM1-71-R2088180-03-2AktPKBProtein kinase BSM1-71 negative control p-AKTS473reversible analog o SM1-71Inhibitorinhibitorinhibit

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产品名称：
SM1-71-R
目录号：
HY-138966
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