1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Solriamfetol

Solriamfetol (Synonyms: JZP-110; ADX-N05; R228060)

目录号: HY-109043
产品使用指南

Solriamfetol (JZP-110) 是一种口服有效的,选择性的多巴胺和去甲肾上腺素再摄取抑制剂,对多巴胺和去甲肾上腺素转运蛋白的 IC50 分别为 2.9 μM 和 4.4 μM。Solriamfetol 具有强大的促唤醒作用。

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Solriamfetol Chemical Structure

Solriamfetol Chemical Structure

CAS No. : 178429-62-4

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Description

Solriamfetol (JZP-110) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol has robust wake-promoting effects[1][2].

IC50 & Target

IC50: 2.9 μM (dopamine transporter) and 4.4 μM (norepinephrine transporter)[1]

In Vitro

Solriamfetol (JZP-110) binds to dopamine and norepinephrine transporters. Solriamfetol has the binding affinity for dopamine transporter (DAT; Ki=14,200 nM) and norepinephrine transporter (NET; Ki=3700 nM)[1].

In Vivo

Solriamfetol (JZP-110; s.c.; 10, 30 mg/kg; eight consecutive 50-minute) increases DA and NE levels in the striatum and prefrontal cortex, respectively[1].
Solriamfetol (i.p.; 3, 10, 30, 100 mg/kg) dose dependently decreases the rate of responding. Solriamfetol of 100 mg/kg results in a significant decrease in response rate to approximately 40% of control[1].
solriamfetol (po; 35 mg/kg) produces a plasma Cmax of 23.1 μM[1].

Animal Model: Male Sprague-Dawley rats weighing 200-400 g[1]
Dosage: 10 and 30 mg/kg
Administration: S.c.; eight consecutive 50-minute
Result: Increased DA and NE levels in the striatum and prefrontal cortex, respectively.
Molecular Weight

194.23

Formula

C₁₀H₁₄N₂O₂

CAS No.

178429-62-4

SMILES

N[C@@H](COC(N)=O)CC1=CC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

SolriamfetolJZP-110ADX-N05R228060JZP110JZP 110R 228060R-228060Dopamine Receptordopaminenorepinephrinereuptaketransportersrobustwake-promotingeffectsInhibitorinhibitorinhibit

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Solriamfetol
目录号:
HY-109043
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