2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. Somatostatin-28 (sheep, human rat mouse)

Somatostatin-28 (sheep, human rat mouse) 

目录号: HY-P3954
产品使用指南

摩尔计算器

Somatostatin-28 (sheep, human rat mouse) 是一种生物活性多肽，在近端肠上皮细胞中合成。Somatostatin-28 (sheep, human rat mouse) 抑制葡萄糖刺激的胰岛素分泌而不影响循环基础胰岛素浓度。Somatostatin-28 (sheep, human rat mouse) 也靶向生长抑素受体 5 亚型 (SSTR5) 调节 GLP-1 分泌。

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Custom Peptide Synthesis

Somatostatin-28 (sheep, human rat mouse) Chemical Structure

Somatostatin-28 (sheep, human rat mouse) Chemical Structure

CAS No. : 73032-94-7

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Somatostatin-28 (sheep, human rat mouse) 相关抗体

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Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion[1][2].

IC50 & Target[2]

SSTR5

 

体外研究
(In Vitro)

Somatostatin-28 剂量依赖地抑制胃泌素释放肽刺激的 GLP-1 分泌，EC50 为 0.01 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Somatostatin-28 (sheep, human rat mouse) 相关抗体:
体内研究
(In Vivo)

Somatostatin-28 (sheep) (1.1 pmol/kg/min; 通过颈静脉导管静脉注射; 15 min) 抑制 25 μg/kg/min 葡萄糖诱导绵羊胰岛素分泌[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)[2]
Dosage: 1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose;
Administration: Intravenous injection via a jugular catheter;
Result: Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.
分子量

3148.56

Formula

C137H207N41O39S3
CAS 号
Sequence

Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge:Cys17-Cys28)
Sequence Shortening

SANSNPAMAPRERKAGCKNFFWKTFTSC (Disulfide bridge: Cys17-Cys28)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Somatostatin-28 (sheep, human rat mouse) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Somatostatin-28 (sheep, human rat mouse)73032-94-7Somatostatin ReceptorSSTRsSSTRInhibitorinhibitorinhibit

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