1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. Talipexole

Talipexole  (Synonyms: B-HT 920)

目录号: HY-A0040
产品使用指南

Talipexole (B-HT920)是多巴胺激动剂,将用于帕金森综合症。

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Talipexole Chemical Structure

Talipexole Chemical Structure

CAS No. : 101626-70-4

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  • 生物活性

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  • 参考文献

生物活性

Talipexole (B-HT920) is a dopamine agonist that has been proposed as an antiparkinsonian agent. Target: Dopamine Receptor B-HT920 is a selective alpha 2-adrenoceptor agonist. The effects of B-HT920 have been specified using the alpha-adrenergic antagonists yohimbine and prazosin and the dopamine antagonist haloperidol. Yohimbine could not antagonize any of the actions of B-HT920. Pretreatment with prazosin showed a decrease in the loss of body weight caused by B-HT920, while pretreatment with yohimbine showed that B-HT920 induced an increased loss in body weight. These data suggest that B-HT920 under certain conditions exerts dopamine-agonistic actions in stimulating locomotor activity and alpha 1-adrenergic actions in inducing salivation and enhanced loss of body weight [1]. Concomitant treatment with talipexole, an anti-parkinsonian drug, inhibited MPTP-induced autolysis and individual death in a concentration-dependent manner. Pramipexole showed a similar protective effect. In addition, post-treatment with talipexole at 1 hr after MPTP completely inhibited MPTP-induced individual death. Although MPTP treatment caused 30% of the planarians to undergo autolysis and individual death within 12 hr, post-treatment with talipexole even at 12 hr completely rescued the remaining 70% of the planarians from death. These results suggest that the MPTP-treated planarian may be useful as a novel parkinsonian model in which talipexole has a protective effect even in the case of post-treatment [2].

分子量

209.31

Formula

C10H15N3S

CAS 号
中文名称

他利克索;坦利噻唑

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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HY-A0040
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