1. Apoptosis
  2. Apoptosis
  3. Tasisulam sodium

Tasisulam sodium (Synonyms: LY 573636 sodium)

目录号: HY-14804A
产品使用指南

Tasisulam 是一种小分子抗肿瘤药物,通过内在途径诱导细胞凋亡,导致细胞色素 c 释放和 caspase 依赖性细胞死亡。Tasisulam 可以抑制有丝分裂进程并诱导血管正常化。

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Tasisulam sodium Chemical Structure

Tasisulam sodium Chemical Structure

CAS No. : 519055-63-1

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Description

Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization[1].

In Vitro

Tasisulam sodium (200 nM-200 μM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s of 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1].
Tasisulam sodium (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1].
Tasisulam sodium (200 nM-200 μM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1].
Tasisulam sodium also blocks VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation[1].

Cell Proliferation Assay[1]

Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models
Concentration: 200 nM-200 μM
Incubation Time: 48 hours
Result: Induced an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: Calu-6 and A-375 cell lines
Concentration: 25, 50 μM
Incubation Time: 72 hours
Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation.

Apoptosis Analysis[1]

Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models
Concentration: 200 nM-200 μM
Incubation Time: 48 hours
Result: Induced apoptosis in a broad range of in vitro cancer cell models.
Molecular Weight

437.09

Formula

C₁₁H₅BrCl₂NNaO₃S₂

CAS No.

519055-63-1

SMILES

O=C(N([Na])S(=O)(C1=CC=C(Br)S1)=O)C2=CC=C(Cl)C=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TasisulamLY 573636LY573636LY-573636ApoptosisInhibitorinhibitorinhibit

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Tasisulam sodium
目录号:
HY-14804A
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