1. Anti-infection
  2. Antibiotic Fungal Bacterial
  3. Terbinafine lactate

Terbinafine lactate  (Synonyms: TDT 067 lactate)

目录号: HY-17395B
产品使用指南

Terbinafine lactate (TDT 067 lactate) 是一种口服有效的抗真菌剂 (antifungal agent)。Terbinafine lactate 是一种对 Candida 的角鲨烯环氧化酶的有效非竞争性抑制剂,其 Ki 为 30 nM。Terbinafine lactate 对某些革兰氏阳性和革兰氏阴性细菌也有抗菌活性。

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Terbinafine lactate Chemical Structure

Terbinafine lactate Chemical Structure

CAS No. : 335276-86-3

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Terbinafine lactate 的其他形式现货产品:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究
(In Vitro)

Terbinafine has a primary fungicidal action in vitro against most fungal pathogens, including dermatophytes, and dimorphic and filamentous fungi. Terbinafine specifically inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation. The treated fungal cells rapidly accumulate tlic intermediate squalene and become deficient in the end-product of the pathway, ergosterol[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Terbinafine is not only active after topical application but is very effective in experimental dermatophytoses following oral administration. In fungi infected guinea-pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

381.51

Formula

C24H31NO3

CAS 号
中文名称

特比萘芬乳酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Terbinafine lactate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Terbinafine lactate
目录号:
HY-17395B
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