1. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Tin protoporphyrin IX dichloride

Tin protoporphyrin IX dichloride  (Synonyms: 锡原卟啉IX; Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX)

目录号: HY-101194 纯度: ≥95.0%
COA 产品使用指南

Tin protoporphyrin IX dichloride (SnPPIX) 是有效的血红素加氧酶-1 (HO-1) 抑制剂。Tin protoporphyrin IX dichloride 使 PDAC 管腺癌肿瘤对化疗敏感。

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Tin protoporphyrin IX dichloride Chemical Structure

Tin protoporphyrin IX dichloride Chemical Structure

CAS No. : 14325-05-4

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1].

IC50 & Target

IC50: Heme oxygenase-1 (HO-1)[1]

体外研究
(In Vitro)

Tin protoporphyrin IX dichloride (20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, Tin protoporphyrin IX dichloride has no significant effect on PDAC cells proliferation at all exposures except at 50 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Capan-1, CD18/HPAF, PDAC cells
Concentration: 20 μM, 50 μM
Incubation Time: 24 or 72 hours
Result: Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.
体内研究
(In Vivo)

Tin protoporphyrin IX dichloride (intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female athymic nude mice with PDAC cell-derived xenograft tumors[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
Result: Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).
分子量

750.26

Formula

C34H32Cl2N4O4Sn

CAS 号
性状

固体

中文名称

锡原卟啉IX

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

0.1 M NaOH 中的溶解度 : 14.29 mg/mL (19.05 mM; 超声助溶; 碱性条件溶解 (NaOH 调节,pH≈11))

1M NaOH 中的溶解度 : 5 mg/mL (6.66 mM; 超声助溶)

DMF 中的溶解度 : 1 mg/mL (1.33 mM; 超声加热助溶)

DMSO 中的溶解度 : 0.5 mg/mL (0.67 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3329 mL 6.6644 mL 13.3287 mL
5 mM 0.2666 mL 1.3329 mL 2.6657 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥95.0%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMF / 1M NaOH / 0.1 M NaOH 1 mM 1.3329 mL 6.6644 mL 13.3287 mL 33.3218 mL
1M NaOH / 0.1 M NaOH 5 mM 0.2666 mL 1.3329 mL 2.6657 mL 6.6644 mL
0.1 M NaOH 10 mM 0.1333 mL 0.6664 mL 1.3329 mL 3.3322 mL
15 mM 0.0889 mL 0.4443 mL 0.8886 mL 2.2215 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Tin protoporphyrin IX dichloride
目录号:
HY-101194
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