2. GPCR/G Protein
  3. GLP Receptor
  4. Tirzepatide TFA

Tirzepatide TFA  (Synonyms: LY3298176 TFA)

目录号: HY-P1731A
COA 产品使用指南

摩尔计算器

Tirzepatide TFA (LY3298176 TFA) 是葡萄糖依赖性胰岛素营养多肽 (GIP) 和胰高血糖素样肽-1 (GLP-1) 受体双重激动剂。Tirzepatide TFA 具有神经保护作用，可以用于2 型糖尿病、糖尿病相关的神经病变和肥胖症的研究。

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Tirzepatide TFA Chemical Structure

Tirzepatide TFA Chemical Structure

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规格 是否有货
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100 mg   询价  
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Tirzepatide TFA 的其他形式现货产品:

Customer Review

Other Forms of Tirzepatide TFA:

Tirzepatide TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tirzepatide TFA (LY3298176 hydrochloride) is a glucose-dependent insulin nutritive polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor dual agonist. Tirzepatide TFA has neuroprotective effects and can be used in the study of type 2 diabetes, diabetes-related neuropathy and obesity[1][2][3].

IC50 & Target

Glucose-dependent insulinotropic polypeptide (GIP), GLP-1 receptor[1]
体外研究
(In Vitro)

Tirzepatide TFA (0-0.4 μM, 7 天) 可以改善高糖诱导的 SHSY5Y 人神经母细胞瘤细胞的神经变性和克服神经元胰岛素抵抗[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tirzepatide TFA 相关抗体:

Western Blot Analysis[1]

Cell Line: SHSY5Y
Concentration: 0-0.4 μM
Incubation Time: 7 days
Result: Upregulated the mRNA expression and protein levels of both CREB and BDNF.
Increased the Bcl-2 and decreased BAX protein levels.
Increased the pAkt, MAP2, GAP43, and AGBL4 protein levels.
Increased GLUT4 and SORBS1 protein levels.
体内研究
(In Vivo)

Tirzepatide TFA (10 nM/kg, 皮下注射) 可抑制饮食性肥胖小鼠结肠癌肿瘤生长[2]。
Tirzepatide TFA (1.35 mg/kg, 腹腔注射, 每周一次) 通过调节糖尿病大鼠异常胰岛素抵抗和炎症反应改善空间学习记忆障碍[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obese (DIO) mice [2]
Dosage: 10 nM/kg
Administration: s.c.
Result: Reduced body weight and food consumption.
Reduced glucose, insulin, leptin, and c-peptide levels.
Animal Model: MC38 colon cancer mice model[2]
Dosage: 10 nM/kg
Administration: s.c.
Result: Reduced tumor volumes.
Clinical Trial
分子量

4813.45 (free base)

Formula

C225H348N48O68.xC2HF3O2
性状

固体

颜色

White to off-white

Sequence

Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{C20 diacid-gamma-Glu-(AEEA)2-Lys}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Sequence Shortening

Y-{Aib}-EGTFTSDYSI-{Aib}-LDKIAQ-{C20 diacid-gamma-Glu-(AEEA)2-Lys}-AFVQWLIAGGPSSGAPPPS-NH2
中文名称

替尔泊肽三氟乙酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Tirzepatide TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TirzepatideLY3298176替尔泊肽三氟乙酸盐LY 3298176LY-3298176GLP ReceptorType 2 diabetesneuropathyAlzheimer's diseaseobesityInhibitorinhibitorinhibit

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