TP-6076 

TP-6076 is a fully synthetic fluorocycline antibiotic, acts function via binding to the 30S ribosomal subunit and maintains its activity. TP-6076 displays potent mechanism-based antitranslational activity (Tet protein, IC₅₀=0.18 μg/mL), shows a wide range of antimicrobial and antiparasitic activities^[1][2].

TP-271 (0.01 ng/mL-100 μg/mL; 72 h) is active in MIC assays against key community respiratory Gram-positive and Gram-negative pathogens^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TP-6076 reduces the bacterial burden in the lung in murine pneumonia models with MRSA, S. pneumoniae, and H. influenzae (1, 5, and 10 mg/kg for i.v.; 12.5, 25, 50 mg/kg for p.o.; single dose), neutropenic murine S. pneumoniae tet(M) pneumonia model (1, 5, and 10 mg/kg for i.v.; 0.3, 3, 10 mg/kg for p.o.; single dose), and immunocompetent mouse S. pneumoniae pneumonia model (30 mg/kg for p.o.; single dose)^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

579.56

C₂₈H₃₂F₃N₃O₇

1575495-01-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rusu A, et al. The Development of Third-Generation Tetracycline Antibiotics and New Perspectives. Pharmaceutics. 2021 Dec 5;13(12):2085.  [Content Brief]

  [2]. Grossman TH, et al. Fluorocycline TP-271 Is Potent against Complicated Community-Acquired Bacterial Pneumonia Pathogens. mSphere. 2017 Feb 22;2(1):e00004-17.  [Content Brief]