2. Antibody-drug Conjugate/ADC Related JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. Antibody-Drug Conjugates (ADCs) EGFR
  4. Trastuzumab deruxtecan (solution)

Trastuzumab deruxtecan (solution)  (Synonyms: DS-8201 (solution); DS-8201a (solution))

目录号: HY-138298 纯度: 99.64%
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Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) 是一种抗人表皮生长因子受体 2 (HER2) 抗体-活性分子偶联物 (ADC)。Trastuzumab deruxtecan 由人源化抗 HER2 抗体、酶促裂解的肽接头、拓扑异构酶 I 抑制剂 (毒素成分 Dxd) 组成。Trastuzumab deruxtecan 可用于 HER2 阳性乳腺癌和胃癌的研究。

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Trastuzumab deruxtecan (solution) Chemical Structure

Trastuzumab deruxtecan (solution) Chemical Structure

CAS No. : 1826843-81-5

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1 mg (10 mg/mL * 100 μL in Aqueous solution) ￥6400
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Trastuzumab deruxtecan (solution) 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

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生物活性

Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer[1][2].

体外研究
(In Vitro)

Trastuzumab deruxtecan (1 pM-10 nM; 5 days) (solution) inhibits the growth of HER2-positive KPL-4 cells, with an IC50 of 109.7 pM[2].
Trastuzumab deruxtecan (10 nM; 5 days) (solution) shows bystander killing effects in HER2-negative MDA-MB-468 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trastuzumab deruxtecan (solution) 相关抗体:

Cell Viability Assay[2]

Cell Line: KPL-4 and MDA-MB-468 cells
Concentration: 1, 10, 100, 1000, 10000 pM
Incubation Time: 5 days
Result: Killed HER2-positive KPL-4 cells only.
体内研究
(In Vivo)

Trastuzumab deruxtecan (3 mg/kg; a single i.v.) (solution) shows antitumor activity against not only HER2-positive tumors but also HER2-negative tumors under the co-inoculated condition[2].
Trastuzumab deruxtecan (10 mg/kg; i.v. on days 0 and 7) (solution) inhibits the tumor growth in in EMT6-hHER2 syngeneic mouse model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice injected with NCI-N87 and MDA-MB-468-Luc cells[2]
Dosage: 3 mg/kg
Administration: A single i.v.
Result: Almost all of the HER2-positive and HER-negative cells disappeared and there were little or no cancer cells remaining in the tumors.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C, protect from light
纯度 & 产品资料

纯度: 99.64%

COA (172 KB) Others (482 KB)

产品使用指南 (1538 KB)
参考文献

Trastuzumab deruxtecan (solution) 相关分类

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Keywords:

Trastuzumab deruxtecan (solution)1826843-81-5DS-8201 (solution) DS-8201a (solution)Antibody-Drug Conjugates (ADCs)EGFRAntibody-Drug ConjugatesEpidermal growth factor receptorErbB-1HER1humanepidermalgrowthfactorHER2antibody-drugconjugateADCantitumorcancerInhibitorinhibitorinhibit

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