2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. α-CGRP (mouse, rat)

α-CGRP (mouse, rat) 是一种神经肽 (降钙素基因相关肽)，主要表达于神经肌肉交界处，是一种有效的血管扩张剂量。α-CGRP (mouse, rat) 可用于心血管、促炎、偏头痛和代谢相关的研究。

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Custom Peptide Synthesis

α-CGRP (mouse, rat) Chemical Structure

α-CGRP (mouse, rat) Chemical Structure

CAS No. : 83651-90-5

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规格 是否有货
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100 mg   询价  
250 mg   询价  

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α-CGRP (mouse, rat) 的其他形式现货产品:

Customer Review

Other Forms of α-CGRP (mouse, rat):

α-CGRP (mouse, rat) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies[1][2][3][4].

体外研究
(In Vitro)

α-CGRP (mouse, rat) 可调节 2 组先天淋巴样细胞反应[1]。
α-CGRP (mouse, rat) 可调节胰岛素分泌，降低 2 型糖尿病的风险[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-CGRP (mouse, rat) 相关抗体:
体内研究
(In Vivo)

α-CGRP (mouse, rat) (0.25, 0.5, 1 μg/kg/min, 静脉注射) 剂量依赖性地降低了平均动脉血压，同时心率和全身血管传导增加，而心输出量保持不变[3]。
α-CGRP (mouse, rat) 在 Kainic acid (KA) 诱导的海马 CA3 区锥体细胞死亡的调控中发挥重要作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3806.25

Formula

C162H262N50O52S2
CAS 号
Sequence

Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
Sequence Shortening

SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (Disulfide bridge:Cys2-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

α-CGRP (mouse, rat) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-CGRP (mouse, rat)83651-90-5CGRP ReceptorCalcitonin gene-related peptide receptorvasodilatorcardiovascularpro-inflammatorymigraineInhibitorinhibitorinhibit

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