12-HETE  (Synonyms: 12-羟基二十碳四烯酸)

12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway^[1].12-HETE has both anti-thrombotic and pro-thrombotic effects^[2]. 12-HETE is a neuromodulator^[3].

12-HETE 通过激活 ILK/NF-κB 通路参与抑制细胞凋亡，这可能是其促进卵巢癌细胞存活的重要机制。12-HETE 通过激活卵巢癌中的整合素连接激酶/NF-κB 通路来促进细胞存活。12-HETE 以浓度依赖性方式防止卵巢癌细胞凋亡。12-HETE (1 μM) 显著降低血清剥夺 (SD) 诱导的 caspase-3 活化。12-HETE 以浓度依赖性方式抑制 SD 诱导的 caspase-3 活性增加，IC₅₀ 值为 1.13 μM^[1]。
12-HETE (1 μM) 通过 ILK 促进卵巢癌细胞中 NF-κB 的活化和核易位^[1]。
12-HETE 抑制胰岛素分泌，降低代谢活性并诱导人类胰岛细胞死亡。12-HETE 增加凝血酶诱导的牛血小板聚集，并抑制前列腺素 E1 诱导的细胞内 cAMP 水平升高。12-HETE 可抑制洗涤性血小板 (WP) 聚集^[2]。
12-HETE 对神经元的影响包括减弱钙内流和谷氨酸释放，以及抑制 AMPA 受体 (AMPA-R) 活化^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

320.47

C₂₀H₃₂O₃

71030-37-0

液体

Colorless to light yellow

12-羟基二十碳四烯酸

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Qian Liu, et al. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. Cancer Manag Res. 2018 Nov 16;10:5825-5838.  [Content Brief]

  [2]. Benedetta Porro, et al. Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:26-40.  [Content Brief]

  [3]. Aidan J Hampson, et al. 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. J Neurosci. 2002 Jan 1;22(1):257-64.  [Content Brief]