1. Stem Cell/Wnt
    TGF-beta/Smad
  2. TGF-beta/Smad

TGF-beta/Smad

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

TGF-beta/Smad 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-13013
    SIS3 Inhibitor >98.0%
    SIS3是可渗透细胞,选择性的 Smad3 抑制剂。 它抑制Smad3磷酸化的IC50 为3 µM。
  • HY-B0673
    Pirfenidone Inhibitor 99.98%
    Pirfenidone是一种用于治疗特发性肺纤维化的药物。 它抑制FGFREGFRPDGFRTGF-β,从而减缓肿瘤细胞增殖。
  • HY-16268
    Kartogenin Activator >98.0%
    Kartogenin是人类间充质干细胞分化成软骨细胞的诱导剂。
  • HY-100347A
    SRI-011381 hydrochloride Agonist 99.66%
    SRI-011381 hydrochloride是TGF-beta信号通路的激活剂。
  • HY-P0118
    Disitertide Inhibitor 98.12%
    Disitertide 是 TGF-β1 的一个抑制剂。
  • HY-N0439
    Asiaticoside Modulator 98.46%
    Asiaticoside 是从积雪草中分到的三萜皂苷化合物,在瘢痕疙瘩成纤维细胞中,通过活化 Smad7,抑制 TGF-βRI 和 TGF-βRII,抑制 TGF-β/Smad 信号通路;Asiaticoside 具有抗氧化、抗炎、抗溃疡等功效。
  • HY-N1584
    Halofuginone Inhibitor
    常山酮 (Halofuginone) 是植物衍生物,能抑制Th17的分化,是一类有高潜力的免疫抑制药物。
  • HY-N0158
    Oxymatrine Inhibitor >98.0%
    Oxymatrine是来自槐属物种根部的生物碱,具有抗炎,抗纤维化和抗肿瘤的作用。能抑制iNOS表达和TGF-β/Smad通路。
  • HY-B0252
    Hydrochlorothiazide Inhibitor 99.20%
    Hydrochlorothiazide是噻嗪类利尿化合物。
  • HY-N2033
    Chebulinic acid Inhibitor
    Chebulinic acid 是一个天然的M. tuberculosis DNA gyrase抑制剂,也能抑制SMAD-3 phosphorylation和H+ K+-ATPase的活性。
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