1. PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. GSK-3

GSK-3

GSK-3 (Glycogen synthase kinase 3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. In mammals GSK-3 is encoded by two known genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B). GSK-3 has recently been the subject of much research because it has been implicated in a number of diseases, including Type II diabetes (Diabetes mellitus type 2), Alzheimer's Disease, inflammation, cancer, and bipolar disorder. Phosphorylation of a protein by GSK-3 usually inhibits the activity of its downstream target. GSK-3 is active in a number of central intracellular signaling pathways, including cellular proliferation, migration, inflammation and immune responses, glucose regulation, and apoptosis.

GSK-3 相关产品 (20):

Cat. No. Product Name Effect Purity
  • HY-10182
    CHIR-99021 Inhibitor 99.92%
    CHIR-99021 是一种 GSK-3α/β 抑制剂,IC50 为 10 nM/6.7 nM。
  • HY-12012
    SB 216763 Inhibitor
    SB 216763 是一种高效的,具有选择性的糖原合成酶激酶3 (GSK-3)抑制剂,IC50 值为 34 nM。
  • HY-10512
    AR-A014418 Inhibitor 99.07%
    AR-A014418 是一种有效的,选择性的 GSK3β 抑制剂,IC50 值为 104 nM。
  • HY-10580
    BIO Inhibitor 98.37%
    BIO 是一种有效的,选择性的 GSK-3CDK1-cyclinB 复合体抑制剂,能够抑制 GSK-3αβ/CDK1/CDK5 的活性,IC50 值分别为 5 nM/320 nM/83 nM。
  • HY-16294
    LY2090314 Inhibitor 99.06%
    LY2090314 是一种有效的 GSK-3 抑制剂,能够作用于 GSK-3α 和 GSK-3β,IC50 值分别为 1.5 nM 和 0.9 nM。
  • HY-10590
    TWS119 Inhibitor 98.35%
    TWS119是GSK-3β抑制剂,IC50为30 nM。
  • HY-15761
    AZD2858 Inhibitor 98.50%
    AZD2858是GSK-3抑制剂,能激活Wnt信号通路。
  • HY-13076
    CHIR-98014 Inhibitor 98.19%
    CHIR-98014是GSK3抑制剂,对GSK-3_alpha_和GSK-3_beta_的IC50分别为0.65 nM和0.58 nM。
  • HY-13862
    AZD1080 Inhibitor 99.10%
    AZD1080 是一种有效的选择性 GSK3 抑制剂。AZD1080 抑制重组人 GSK3αGSK3βpKi (IC50) 分别为 8.2 (6.9 nM) 和 7.5 (31 nM)。
  • HY-14872
    Tideglusib Inhibitor 99.81%
    Tideglusib 是一种不可逆的 GSK-3 抑制剂,作用于 GSK-3βWTGSK-3βC199AIC50 分别为 5 nM 和 60 nM。
  • HY-100207
    CP21R7 Inhibitor
    CP21R7是强的和选择性的GSK-3β抑制剂。
  • HY-12302
    Kenpaullone Inhibitor 98.09%
    Kenpaullone是一种ATP竞争性的CDKs和GSK-3β抑制剂, 抑制 GSK-3β, CDK1/cyclin B, CDK2/cyclin A, CDK5/p25, 和 lymphocyte kinase 时, IC50值分别为0.23 μM, 0.4μM, 0.68μM, 0.85μM, 和 0.47 μM。
  • HY-15438
    SB 415286 Inhibitor 99.51%
    SB 415286是可渗透入细胞的ATP竞争性GSK3α选择性抑制剂,IC50和Ki分别为78 nM和31nM。
  • HY-11012
    TDZD-8 Inhibitor 99.07%
    TDZD-8(NP 01139)是thiadiazolidinone的衍生物,是非ATP竞争性GSK-3β抑制剂,IC50为2 μM,对Cdk-1/cyclin B,CK-II,PKA和PKC无活性。
  • HY-10182B
    CHIR-99021 trihydrochloride Inhibitor 99.02%
    CHIR-99021 (CT99021) 是一个GSK-3α/β的抑制剂。
  • HY-19807
    Indirubin-3'-monoxime Inhibitor 99.70%
    Indirubin-3'-monoxime是有效的 GSK-3β抑制剂, IC50为 22nM, 也抑制 CDK1/5 (IC50 = 180/100 nM)。
  • HY-12524
    Bikinin Inhibitor
    Bikinin(Abrasin)是植物GSK-3/Shaggy-like kinase高效抑制剂,活化油菜素内酯(BR)受体的下游信号。
  • HY-12292
    IM-12 Inhibitor
    IM-12是GSK-3β的有效抑制剂,IC50值为53nM,相比SB-216763,活性相当甚至要更好。
  • HY-10182A
    CHIR-99021 monohydrochloride Inhibitor
    CHIR-99021 (CT99021) 是一个GSK-3α/β的抑制剂。
  • HY-13973A
    GSK-3 inhibitor 1 Inhibitor
    GSK-3 inhibitor 1是GSK-3抑制剂。