1. MAPK/ERK Pathway
  2. MAP4K

MAP4K

MAP4Ks (Mitogen-activated protein kinase kinase kinase kinases) belong to the mammalian Ste20-like family of serine/threonine kinases. MAP4K family members, including Hematopoietic progenitor kinase 1 (HPK1/MAP4K1), Germinal centre kinase (GCK/MAP4K2), Germinal centre kinase-like kinase (GLK/MAP4K3), HPK/GCK-like kinase (HGK/MAP4K4), Misshapen-like kinase 1 (MINK1/MAP4K6) and TRAF2 and NCK interacting kinase (TNIK/MAP4K7), as potent LATS1/2-activating kinases.

Overexpression or deletion of MAP4Ks affects the phosphorylation and activity of Large tumor suppressor 1/2 (LATS1/2, homologues of Wts) and Yes-associated protein (YAP) /transcriptional co-activator with PDZ-binding motif (TAZ). By acting in a LATS-dependent, but Mammalian Ste20-like kinases 1/2 (MST1/2, homologues of Hpo)-independent manner, MAP4Ks restrict the activity of YAP/TAZ by promoting their phosphorylation and inhibiting target gene expression. MAP4Ks are components of the Hippo pathway by directly phosphorylating and activating the LATS1/2 kinases.MAP4K2/4/6 and MST1/2 both belong to the STE20-like kinase family, and their kinase domains are highly homologous to one another. MAP4K4 acts through LATS to inhibit YAP and cell proliferation.

MAP4K 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-15434
    NG25 Inhibitor 99.45%
    NG25 是一种 TAK1MAP4K2 的双重抑制剂,IC50 值分别为 149 nM 和 21.7 nM。
  • HY-100343
    GNE-495 Inhibitor 98.79%
    GNE-495 是一种有效的选择性 MAP4K4 抑制剂,IC50 为 3.7 nM。
  • HY-100830
    NCB-0846 Inhibitor 98.27%
    NCB-0846是具有口服活性的TNIK抑制剂,IC50值为21 nM。
  • HY-19562
    PF-06260933 Inhibitor 99.69%
    PF-06260933 是一种高度选择性的 MAP4K4 小分子抑制剂,在激酶实验和细胞实验中的 IC50 值分别为 3.7 和 160 nM。
  • HY-U00428
    GNE 220 Inhibitor
    GNE-220 是一种有效的选择性 MAP4K4 抑制剂,IC50 为 4 nM。