1. Stem Cell/Wnt
  2. Hedgehog

Hedgehog

Hedgehog (Hh) is composed of N-terminal and C-terminal domains that dissociate in a self-catalyzed proteolytic cleavage reaction. The N-terminal product HhNp, modified by cholesterol during self-cleavage, harbors all known Hh signaling activities. When synthesized in the absence of the C-terminal domain (and hence lacking cholesterol modification), the N-terminal domain is aberrantly targeted and released selectively into the retina.

Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. Hh ligands bind to and suppress the transmembrane receptor Patched (PTCH), which suppresses Smoothened (SMO), a seven-transmembrane-helix protein that positively regulates the Hh pathway.

Sonic hedgehog (Shh) is a morphogen essential to the developing nervous system that continues to play an important role in adult life by contributing to cell proliferation and differentiation, maintaining blood-brain barrier integrity, and being cytoprotective against oxidative and excitotoxic stress, all features of importance in amyotrophic lateral sclerosis (ALS).

Indian hedgehog (Ihh), a signaling molecule that plays a pivotal role in the regulation of chondrocyte proliferation, maturation, and ossification both in long-bone development and digit joint formation, has also been found to be essential for temporomandibular joint (TMJ) development.

Desert hedgehog (Dhh), one of the Hedgehog family members, is expressed by Schwann cells of peripheral nerves.

Hedgehog 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-17024
    Cyclopamine Antagonist >98.0%
    Cyclopamine 是一种 Hedgehog (Hh) 通道拮抗剂,在 Hh 细胞实验中,IC50 为 46 nM。
  • HY-10440
    Vismodegib Inhibitor 98.95%
    Vismodegib 是一种可口服的 hedgehog 抑制剂,IC50 值为 3 nM;同时可抑制 P-gp 和 ABCG2 的活性,IC50 值分别为 3.0 μM 和 1.4 μM。
  • HY-18366A
    RU-SKI 43 hydrochloride Inhibitor >98.0%
    RU-SKI 43盐酸盐是Hhat新型小分子抑制剂。
  • HY-N0836
    Jervine Inhibitor 99.03%
    Jervine(11-Ketocyclopamine)是甾体类生物碱,能阻断sonic hedgehog(Shh)信号通路,抑制Smo。
  • HY-100790
    Ciliobrevin A Inhibitor 98.34%
    Ciliobrevin A 是一种 Hedgehog (Hh) 信号通路抑制剂,平均抑制浓度 (50) 值小于 10 μM。
  • HY-13307
    JK184 Inhibitor 99.74%
    JK184 是一种有效的 Hedgehog (Hh) 抑制剂,在哺乳动物细胞中,IC50 为 30 nM。
  • HY-18366
    RU-SKI 43 Inhibitor
    RU-SKI 43是Hedgehog乙酰转移酶Hhat抑制剂。