1. Apoptosis
  2. Apoptosis

Apoptosis

Apoptosis is one of the major pathways of programmed cell death.

Apoptosis or programmed cell death is a critical cellular process for the maintenance of tissue homeostasis and normal development of multicellular organisms. Inappropriate regulation of apoptosis signaling pathways may lead to several diseases including cancer. In tumor cells, the pathways that lead to apoptosis are disrupted or impaired due to which cells undergo malignant transformation.Therefore, targeting critical apoptosis regulators with a goal to induce apoptosis in cancer cells has emerged as an attractive strategy in cancer chemotherapy. DNA topoisomerase (topo) is recognized as an important target in anticancer drug discovery.

ROS production in cancer cells regulates cellular growth, cell signaling and synthesis of important substances. Furthermore, mitochondria plays an important role for the survival of cancercells, hence disrupting mitochondrial function by small molecules induces apoptosis.

Apoptosis 相关产品 (34):

Cat. No. Product Name Effect Purity
  • HY-17394
    Cisplatin Activator >98.00%
    Cisplatin 是一种有效的生长停滞和/或细胞凋亡 (apoptosis) 诱导剂。
  • HY-N0848
    Epibrassinolide Activator >98.00%
    Epibrassinolide 是一种天然油菜素类固醇(BR)衍生物,是一种植物调节剂,具有与哺乳动物类固醇相似的结构。Epibrassinolide在各种癌细胞中是一种潜在的凋亡诱导剂,而不影响非肿瘤细胞生长。
  • HY-14808
    Adarotene Activator 99.15%
    Adarotene 是一种有效的 apoptosis 诱导剂,通过产生 DNA 损伤,来阻止人类肿瘤细胞的增殖。
  • HY-12040
    Elesclomol Activator 99.43%
    Elesclomol 是一种有效的氧化应激诱导物,在肿瘤细胞中,引起促凋亡活动。
  • HY-10529
    Betulinic acid Activator 98.58%
    Betulinic acid能诱导肿瘤细胞凋亡,还可抑制HIV-1,EC50为1.4 μ M。
  • HY-101103
    (2-Hydroxypropyl)-β-cyclodextrin >98.0%
    (2-Hydroxypropyl)-β-cyclodextrin是广泛使用的药物递送载体,可提高稳定性和利用度。
  • HY-N1428
    Citric acid Inhibitor >98.0%
    Citric acid是柑橘类水果中发现的弱有机三羧酸。柠檬酸是天然防腐剂和食品添加剂。
  • HY-N0362
    Columbianadin Activator 99.85%
    Columbianadin 是来自 Angelica decursiva (Umbelliferae) 中的天然香豆素,已知具有各种生物活性,包括抗炎和抗癌作用。
  • HY-15097
    Myricetin Activator 99.41%
    Myricetin是常见的植物来源的类黄酮,具有广泛的活性,包括强抗氧化,抗癌,抗糖尿病和抗炎活性。
  • HY-N2027
    Taurochenodeoxycholic acid Activator 99.80%
    Taurochenodeoxycholic acid是动物胆汁酸的主要生物活性物质之一。
  • HY-N0083
    Betulin Activator >98.0%
    Betulin是一种SREBP抑制剂,在K562细胞中的IC50值是14.5 μM。
  • HY-13915
    NSC348884 Activator 99.92%
    NSC348884是核磷蛋白抑制剂, 破坏低聚物形成和诱导细胞凋亡,抑制不同癌细胞系增殖, IC 50为1.7-4.0 μM。
  • HY-N2338
    Cholesterol myristate Inhibitor >98.0%
    胆固醇肉豆蔻酸酯是中药中天然类固醇。
  • HY-13680
    Meisoindigo Activator
    Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III)可诱导急性髓性白血病的凋亡和髓样分化。
  • HY-15694
    SMIP004 Activator 98.11%
    SMIP004是新型人前列腺癌细胞选择性凋亡诱导剂,能下调SKP2,稳定p27。
  • HY-18633
    Apoptosis Activator 2 Activator 98.58%
    Apoptosis Activator 2是细胞凋亡有效激活剂,能促进procaspase-9的加工并活化caspase-3。
  • HY-50936
    Trabectedin Activator
    Trabectedin (Ecteinascidin-743 or ET-743)是海洋来源的抗癌剂。
  • HY-14615
    [6]-Gingerol Activator 98.01%
    [6]-Gingerol是从生姜中分离的活性物质,具有多种生物活性,包括抗癌,抗炎和抗氧化。
  • HY-77293
    (E)-[6]-Dehydroparadol Activator 98.87%
    (E)-[6]-Dehydroparadol来自专利US 9272994化合物M15, 能够抑制人体癌细胞生长并且诱导细胞凋亡。在HCT-116和H-1299细胞中的IC50值分别为43.02和 41.59 μM。
  • HY-100738
    Ubiquitin Isopeptidase Inhibitor I, G5 Activator >98.0%
    Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依赖的半胱天冬酶和细胞凋亡的激活剂,对E1A和E1A/C9DN细胞的IC50值分别为1.76和1.6 μM。