1. Apoptosis
  2. Apoptosis

Apoptosis

Apoptosis is a distinctive form of cell death exhibiting specific morphological and biochemical characteristics, including cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and exposure of specific phagocytosis signaling molecules on the cell surface. Cells undergoing apoptosis differ from those dying through necrosis. Necrotic cells are usually recognized by the immune system as a danger signal and, thus, resulting in inflammation; in contrast, apoptotic death is quiet and orderly.

There are two major pathways of apoptotic cell death induction: The intrinsic pathway, also called the Bcl-2-regulated or mitochondrial pathway, is activated by various developmental cues or cytotoxic insults, such as viral infection, DNA damage and growth-factor deprivation, and is strictly controlled by the BCL-2 family of proteins. The extrinsic or death-receptor pathway is triggered by ligation of death receptors (members of the tumor necrosis factor (TNF) receptor family, such as Fas or TNF receptor-1 (TNFR1)) that contain an intracellular death domain, which can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface. This recruitment causes subsequent activation of downstream (effector) caspases, such as caspase-3, -6 or -7, without any involvement of the BCL-2 family.

Studies suggest that alterations in cell survival contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome). Treatments designed to specifically alter the apoptotic threshold may have the potential to change the natural progression of some of these diseases.

Apoptosis 相关产品 (39):

Cat. No. Product Name Effect Purity
  • HY-17394
    Cisplatin Activator >99.0%
    Cisplatin 是一种有效的生长停滞和/或细胞凋亡 (apoptosis) 诱导剂。
  • HY-N0848
    Epibrassinolide Activator >98.00%
    Epibrassinolide 是一种天然油菜素类固醇(BR)衍生物,是一种植物调节剂,具有与哺乳动物类固醇相似的结构。Epibrassinolide在各种癌细胞中是一种潜在的凋亡诱导剂,而不影响非肿瘤细胞生长。
  • HY-14808
    Adarotene Activator 99.15%
    Adarotene 是一种有效的 apoptosis 诱导剂,通过产生 DNA 损伤,来阻止人类肿瘤细胞的增殖。
  • HY-12040
    Elesclomol Activator 99.80%
    Elesclomol 是一种有效的氧化应激诱导物,在肿瘤细胞中,引起促凋亡活动。
  • HY-101103
    (2-Hydroxypropyl)-β-cyclodextrin
    (2-Hydroxypropyl)-β-cyclodextrin是广泛使用的药物递送载体,可提高稳定性和利用度。
  • HY-U00446
    PBOX 6 Activator
    PBOX 6 是一种 pyrrolo-1,5-benzoxazepine (PBOX) 化合物,可作为微管解聚剂和促凋亡剂起作用。
  • HY-15097
    Myricetin Activator 99.41%
    Myricetin是常见的植物来源的类黄酮,具有广泛的活性,包括强抗氧化,抗癌,抗糖尿病和抗炎活性。
  • HY-10529
    Betulinic acid Activator 98.58%
    Betulinic acid 是一种天然的五环三萜类化合物,为真核细胞拓扑异构酶 I (topoisomerase I) 的抑制剂,IC50 值为 5 μM,具有抗炎,抗疟疾,抗艾滋病和抗肿瘤等活性。
  • HY-N2027
    Taurochenodeoxycholic acid Activator 99.80%
    Taurochenodeoxycholic acid是动物胆汁酸的主要生物活性物质之一。
  • HY-50936
    Trabectedin Activator
    Trabectedin (Ecteinascidin-743 or ET-743)是海洋来源的抗癌剂。
  • HY-100738
    Ubiquitin Isopeptidase Inhibitor I, G5 Activator >98.0%
    Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依赖的半胱天冬酶和细胞凋亡的激活剂,对E1A和E1A/C9DN细胞的IC50值分别为1.76和1.6 μM。
  • HY-N0605
    Ginsenoside Rh2 Activator >98.0%
    Ginsenoside Rh2 是从 Ginseng 根中分离出来的。Ginsenoside Rh2 诱导 caspase-8caspase-9 活化。Ginsenoside Rh2 以多途径方式诱导癌细胞凋亡。
  • HY-N0780
    Isoalantolactone Activator 99.92%
    Isoalantolactone 是一种烷化剂,用作细胞凋亡 (apoptosis) 诱导剂。
  • HY-N0083
    Betulin Activator >98.0%
    Betulin是一种SREBP抑制剂,在K562细胞中的IC50值是14.5 μM。
  • HY-14615
    [6]-Gingerol Activator 98.01%
    [6]-Gingerol是从生姜中分离的活性物质,具有多种生物活性,包括抗癌,抗炎和抗氧化。
  • HY-13915
    NSC348884 Activator 99.92%
    NSC348884是核磷蛋白抑制剂, 破坏低聚物形成和诱导细胞凋亡,抑制不同癌细胞系增殖, IC 50为1.7-4.0 μM。
  • HY-N0120A
    Polydatin 98.42%
    Polydatin提取自从传统中药虎杖根,在多个实验模型中具有抗炎作用。
  • HY-13680
    Meisoindigo Activator
    Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III)可诱导急性髓性白血病的凋亡和髓样分化。
  • HY-N0036
    Costunolide Activator 99.62%
    Costunolide有抗炎和抗氧化活性,能介导凋亡。
  • HY-15694
    SMIP004 Activator 98.81%
    SMIP004是新型人前列腺癌细胞选择性凋亡诱导剂,能下调SKP2,稳定p27。