1. Neuronal Signaling
  2. CaMK

CaMK

The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.

Calcium/calmodulin kinase II (CaMK II) is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.

Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the Ca2+/calmodulin (CaM) dependent kinases (CaMKs) which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.

CaMK 相关产品 (19):

Cat. No. Product Name Effect Purity
  • HY-15465
    KN-93 Inhibitor 98.79%
    KN-93是可渗透细胞,可逆和竞争性的抑制剂钙调蛋白依赖性激酶II型 (CaMKII) 抑制剂,Ki 为370 nM。
  • HY-19805
    STO-609 Inhibitor >98.0%
    STO-609是选择性和细胞可渗透的CaM-KK抑制剂, 对重组CaM-KKα和 CaM-KKβ的Ki值分别为80和15 ng/mL。
  • HY-15465B
    KN-93 phosphate Inhibitor 99.91%
    KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。
  • HY-13290
    KN-62 Inhibitor 99.16%
    KN-62 是一种有效的选择性的钙调蛋白依赖性蛋白激酶 II (CaMK-II)抑制剂,IC50 为 0.9 μM,在HEK293 细胞中,KN-62 也非竞争性拮抗P2X7 受体,IC50 约为 15 nM。
  • HY-15517B
    KN-92 hydrochloride Inhibitor 99.77%
    KN-92是KN-93的非活性衍生物。KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。
  • HY-P0214A
    Autocamtide-2-related inhibitory peptide TFA Inhibitor 98.48%
    Autocamtide-2-related inhibitory peptide (TFA) 是高度特异性的、CaMKII 的有效抑制剂,其 IC50 值为 40 nM。
  • HY-110096
    A-484954 Inhibitor 98.01%
    A-484954 是真核延长因子 2 (eEF2) 的高度选择性抑制剂,其 IC50 值为 280 nM。
  • HY-100576
    NH125 Inhibitor
    NH125 是真核延长因子 2 激酶 (eEF-2K/CaMKIII) 的有效选择性抑制剂,能够诱导 eEF2 磷酸化,其对 eEF-2K 的 IC50 值为 60 nM。
  • HY-15465A
    KN-93 hydrochloride Inhibitor 99.67%
    KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。
  • HY-15517A
    KN-92 phosphate Inhibitor 99.94%
    KN-92是KN-93的非活性衍生物。KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。
  • HY-P1029
    MLCK inhibitor peptide 18 Inhibitor 98.71%
    MLCK inhibitor peptide 18 是一种有效的 MLCK 抑制剂,IC50 值为 50 nM,同时较弱抑制 CaM kinase II 的活性。
  • HY-18271
    CaMKII-IN-1 Inhibitor 98.09%
    CaMKII-IN-1是CaMKII高效选择性抑制剂,IC50值为63nM,对CaMKIV, MLCK, p38a, Akt1,和PKC几乎无作用。
  • HY-P0225
    Autocamtide 2 98.17%
    Autocamtide 2是钙/钙调蛋白依赖的蛋白激酶II (CaMKII)的高选择性肽底物。 它可以用于测定CaMKII的活力。
  • HY-15517
    KN-92 Inhibitor
    KN-92是KN-93的非活化衍生物。KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。
  • HY-P0271
    Syntide 2
    Syntide 2是可被Ca2+/钙调蛋白依赖性蛋白激酶II (CaMKII) 识别的底物。
  • HY-100779
    Rimacalib Inhibitor
    Rimacalib 是 CaMKII 的抑制剂,其对 CaMKII 亚型的 IC50 值为 1-30 μM。
  • HY-P1528
    Autocamtide 2, amide
    Autocamtide 2, amide是钙调蛋白激酶 (CaMK) 家族实验的底物(100 μM final concentration)。
  • HY-P1479
    Calmodulin-Dependent Protein Kinase II 290-309 Antagonist
    Calmodulin-Dependent Protein Kinase II (290-309) 是有效的 CaMK 拮抗剂, 抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的 IC50 值为52 nM。
  • HY-100263
    Metofenazate Inhibitor
    Metofenazate 是一个选择性的钙调蛋白抑制剂。
Isoform Specific Products

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