1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK

AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

AMPK 相关产品 (24):

Cat. No. Product Name Effect Purity
  • HY-13418
    Dorsomorphin dihydrochloride Inhibitor 99.73%
    Dorsomorphin dihydrochloride 是一种有效的ATP竞争性的选择性AMPK 抑制剂,Ki 为 109±16 nM。
  • HY-17471A
    Metformin hydrochloride Activator 99.08%
    Metformin hydrochloride 是一种治疗Ⅱ型糖尿病的一线药物,同时也有证据表明该药物具有抗癌的效果。
  • HY-13417
    AICAR Activator 99.84%
    AICAR 是一种AMP活化蛋白激酶 (AMPK)激活剂,下调HepG2细胞中的胰岛素受体表达。
  • HY-50662
    A-769662 Activator 98.80%
    A-769662 是一种有效的,可逆的 AMPK 激活剂,EC50 值为 0.8 μM,对GPPase/FBPase的作用很小。
  • HY-15802
    WZ4003 Inhibitor
    WZ4003 是一种有效的,高度特异性的 NUAK kinase 抑制剂,能够抑制 NUAK1/NUAK2 的活性,IC50 值分别为 20 nM/100 nM。
  • HY-P0136
    SAMS
    SAMS肽是特异性的AMP活化蛋白激酶 (AMPK) 底物。
  • HY-16397A
    Phenformin hydrochloride Activator 98.17%
    Phenformin hydrochloride 是一种双胍类的抗糖尿病药,能够使 AMPK 活化。
  • HY-12357
    ETC-1002 Activator >98.0%
    ETC-1002(ESP-55016)是AMPK的激活剂; 也是ACL的抑制剂,IC50值为29 μM.
  • HY-12831
    Ampkinone Activator 98.11%
    Ampkinone是AMPK小分子激活剂,通过Thr172的磷酸化激活AMPK活性,增强葡萄糖的吸收,EC50值4.3uM。
  • HY-16708A
    ZLN024 hydrochloride Activator 98.88%
    ZLN024盐酸盐是AMPK变构激动剂,能激活_alpha_1_beta_1_gamma_1和_alpha_2_beta_1_gamma_1,EC50值为1-2uM。
  • HY-12334
    HTH-01-015 Inhibitor 99.65%
    HTH-01-015是一高效选择性NUAK1抑制剂,IC50值为100nM,对NUAK2无明显抑制(IC50>10uM)。
  • HY-14537
    Latrepirdine dihydrochloride Activator 99.75%
    Latrepirdine是一个强的AMPK激活剂,也是抗组胺,能够促进α-synuclein蛋白聚合的移动。
  • HY-15840
    YLF-466D Inhibitor 99.16%
    YLF-466D是AMPK变构活化剂,能激活人重组型α1β1γ1,α2β1γ1和鼠肝AMPK。
  • HY-B0923
    Danthron Activator >98.0%
    Danthron是合成的蒽醌衍生物,目前用作合成润滑剂的抗氧化剂,在抗肿瘤剂的合成中,作为杀真菌剂,及作为中间体用于制备染料。
  • HY-14615
    [6]-Gingerol Activator 98.01%
    [6]-Gingerol是从生姜中分离的活性物质,具有多种生物活性,包括抗癌,抗炎和抗氧化。
  • HY-13417A
    AICAR phosphate Activator >98.0%
    AICAR磷酸盐(Acadesine)是AMPK活化剂。
  • HY-N0109
    Salidroside Activator 98.46%
    Salidroside 是一个有活性的酚糖苷化合物,从红景天中分离得到。
  • HY-13418A
    Dorsomorphin Inhibitor
    Dorsomorphin(Compound C; BML-275)是AMPK选择性抑制剂,Ki为109 nM,还能抑制ALK2,ALK3和ALK6。
  • HY-N0857
    Deoxyandrographolide Activator
    去氧穿心莲内酯 (Deoxyandrographolide) 是天然提取化合物,被报道有抗肝癌和胆管癌细胞(HuCCA-1和RMCCA-1细胞)。
  • HY-14771A
    Imeglimin hydrochloride Activator >98.0%
    Imeglimin(EMD 387008)是针对2型糖尿病的口服制剂。