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AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

AMP-activated protein kinase (17)
产品名称 目录号 简述
A-769662 HY-50662

A-769662是可逆的AMPK活化剂,EC50为800nM,对GPPase/FBPase几乎无活性。

AICAR HY-13417

AICAR (阿卡地新; Acadesine) 是AMPK活化剂,可作用于急性淋巴细胞白血病。

AICAR phosphate HY-13417A

AICAR磷酸盐(Acadesine)是AMPK活化剂。

Ampkinone HY-12831

Ampkinone是AMPK小分子激活剂,通过Thr172的磷酸化激活AMPK活性,增强葡萄糖的吸收,EC50值4.3uM。

Dorsomorphin HY-13418A

Dorsomorphin(Compound C; BML-275)是AMPK选择性抑制剂,Ki为109 nM,还能抑制ALK2,ALK3和ALK6。

Dorsomorphin dihydrochloride HY-13418

Dorsomorphin(Compound C; BML-275)双盐酸盐是AMPK选择性抑制剂,Ki为109 nM,还能抑制ALK2,ALK3和ALK6。

ETC-1002 HY-12357

ETC-1002(ESP-55016)是AMPK口服活性激动剂,同时也是ATP-citrate lyase的抑制剂,IC50值为29uM。

HTH-01-015 HY-12334

HTH-01-015是一高效选择性NUAK1抑制剂,IC50值为100nM,对NUAK2无明显抑制(IC50>10uM)。

Imeglimin HY-14771

Imeglimin(EMD-387008)是口服的抗糖尿病化合物,可作用于肝,肌肉和胰腺中的β细胞。

Imeglimin hydrochloride HY-14771A

Imeglimin(EMD 387008)是针对2型糖尿病的口服制剂。

Latrepirdine dihydrochloride HY-14537

Latrepirdine (dihydrochloride) is a potent activator of AMPK, also an anti-histamine, promote the removal of α-synuclein protein aggregates.

Palmitelaidic Acid HY-N2341

Palmitelaidic acid is the trans isomer of palmitoleic acid.

WZ4003 HY-15802

WZ4003是第一个高特异性NUAK抑制剂,对NUAK1和NUAK2的IC50分别为20 nM和100 nM,对其它139种激酶则无明显抑制性。

YLF-466D HY-15840

YLF-466D是AMPK变构活化剂,能激活人重组型α1β1γ1,α2β1γ1和鼠肝AMPK。

ZLN024 HY-16708

ZLN024是AMPK变构激动剂,能激活_alpha_1_beta_1_gamma_1和_alpha_2_beta_1_gamma_1,EC50值为1-2uM。

ZLN024 hydrochloride HY-16708A

ZLN024盐酸盐是AMPK变构激动剂,能激活_alpha_1_beta_1_gamma_1和_alpha_2_beta_1_gamma_1,EC50值为1-2uM。

[6]-Gingerol HY-14615

[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

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