1. Apoptosis
  2. Survivin

Survivin

Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in tumour growth. Survivin expression is highly regulated by the cell cycle and is only expressed in the G2-M phase. Survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Survivin is highly expressed in most cancers and associated with chemotherapy resistance, increased tumor recurrence, and shorter patient survival, making antisurvivin therapy an attractive cancer treatment strategy.

Survivin 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-10194
    YM-155 Inhibitor >98.0%
    YM-155 是一种 survivin 抑制剂,能够抑制 survivin 启动子的活动,IC50 值为 0.54 nM。
  • HY-10194A
    YM-155 hydrochloride Inhibitor
    YM155盐酸盐是新型survivin抑制剂,对survivin启动子的IC50为0.54 nM。