1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR

ATM/ATR

ATM/ATR are members of the PI3 family of serine-threonine kinases and function as essential links between the sensors and effectors of the DNA damage response. The roles of ATM and ATR partially overlap and are cooperative; however they are also known to play distinct roles in protecting the cell from DNA damage. ATM is mostly responsible for sending signals from DSBs (double-strand breaks) induced by ionizing radiation while the closely related ATR responds to UV damage or stalled replication forks. ATM and ATR are known to phosphorylate common as well as specific substrates to activate checkpoint signaling. The G1, S, and G2 cell cycle checkpoints are primarily regulated by the ATM (ataxia telangiectasia, mutated) and ATR (ATM and Rad3-related) protein kinases.

ATM/ATR 相关产品 (14):

Cat. No. Product Name Effect Purity
  • HY-10197
    Wortmannin Inhibitor 99.65%
    Wortmannin 是一种多靶点抑制剂,抑制 PI3K 和 MLCK 活性,IC50 分别为 3 nM 和 200 nM。并有效抑制 DNA-PK 和 ATM,IC50 分别为 16 nM 和 150 nM。
  • HY-19323
    AZD6738 Inhibitor 99.33%
    AZD6738是有效地ATR激酶抑制剂,IC50值为1 nM。
  • HY-13902
    VE-822 Inhibitor 99.22%
    VE-822 是一种 ATR 抑制剂,Ki值 <0.2 nM,也抑制 ATMKi 为 34 nM。
  • HY-14731
    VE-821 Inhibitor 99.47%
    VE-821 是一种有效的 ATP 竞争性的 ATR 抑制剂,Ki/IC50 为 13 nM/26 nM。
  • HY-12016
    KU-55933 Inhibitor 99.67%
    KU-55933 是一种有效的 ATM 抑制剂,IC50Ki 值分别为 12.9 和 2.2 nM;对 ATM 的选择性比对 DNA-PK,PI3K/PI4K,ATR 和 mTOR 高。
  • HY-101566A
    BAY-1895344 hydrochloride Inhibitor 99.04%
    BAY-1895344 hydrochloride 是一种有效的,可口服的,选择性的 ATM 抑制剂,IC50 值为 7 nM。
  • HY-109566
    AZD1390 Inhibitor
    AZD1390 是一种 ATM 抑制剂。
  • HY-12061
    KU-60019 Inhibitor 99.27%
    KU-60019 是一种 ATM 激酶特异性的抑制剂,IC50 为 6.3 nM。
  • HY-100016
    AZD0156 Inhibitor 99.60%
    AZD0156 是一种有效的,可口服的,选择性的 ATM kinase 抑制剂,常用于癌症治疗。
  • HY-11002
    CP-466722 Inhibitor 98.40%
    CP-466722 是一种可逆的 ATM 抑制剂,但对 PI3K,PIKK 家族蛋白没有作用。
  • HY-15557
    AZ20 Inhibitor 99.56%
    AZ20 是一种有效的,选择性的 ATR 抑制剂,IC50 值为 5 nM;同时可抑制 mTOR 活性,IC50 值为 38 nM。
  • HY-15520
    CGK733 Inhibitor 99.66%
    CGK733 是一种有效的 ATM/ATR 抑制剂,对 ATM 和 ATR 的 IC50 值均约为 200 nM。
  • HY-16667
    HLM006474 Inhibitor 99.25%
    HLM006474 是一种光谱的 E2F 抑制剂,在 A375 细胞中,可抑制 E2F4 DAN 结合,IC50 值为 29.8 µM。
  • HY-15521
    ETP-46464 Inhibitor 99.34%
    ETP-46464 是一种有效的 mTORATR 抑制剂,IC50 分别为 0.6 和 14 nM。