1. GPCR/G Protein
  2. CCR


CCR (Chemokine receptors) are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called achemokine. There have been 19 distinct chemokine receptors described in mammals. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. Specific chemokine receptors provide the portals for HIV to get into cells, and others contribute to inflammatory diseases and cancer.

CCR 相关产品 (31):

Cat. No. Product Name Effect Purity
  • HY-13004
    Maraviroc Antagonist 99.71%
    Maraviroc 是一种选择性的 CCR5 拮抗剂,抑制 MIP-1α (IC50,3.3 nM),MIP-1β (IC50,7.2 nM) 和 RANTES (IC50,5.2 nM) 结合到表达 CCR5 的 HEK-293 细胞膜。
  • HY-13245
    PF-4136309 Antagonist 99.59%
    PF-4136309 是一种高效,具有选择性,可口服的 CCR2 拮抗剂,能够抑制人体,小鼠和大鼠 CCR2,IC50 值分别为 5.2 nM,17 nM 和 13 nM。
  • HY-50674
    INCB3344 Antagonist 99.76%
    INCB3344 是一种有效的 CCR2 拮抗剂,拮抗结合活性时,IC50 为 5.1 nM (hCCR2) 和 9.5 nM (mCCR2),拮抗趋化活性时,IC50 为 3.8 nM (hCCR2) 和 7.8 nM (mCCR2)。
  • HY-12080
    BX471 Antagonist
    BX471 是以一种有效的,选择性的,非肽段的 CCR1 拮抗剂,抑制人 CCR1 活性,Ki 值为 1 nM,对其选择性是对 CCR2,CCR5 和 CXCR4 的 250 倍。
  • HY-14882
    Cenicriviroc Antagonist
    Cenicriviroc 是一种可口服的 CCR2/CCR5 双重抑制剂,具有显著的抗炎、抗感染的功效。
  • HY-100183
    GSK2239633A Antagonist
    GSK2239633A 是一种 CC 趋化因子受体4 (CCR4) 拮抗剂,抑制 [125I]-TARC 与人 CCR4 结合,pIC50 为 7.96±0.11。
  • HY-100261
    CCR5 antagonist 1 Antagonist
    CCR5 antagonist 1 是一个 CCR5 拮抗剂, 能够抑制 HIV 病毒的复制来自专利 WO 2004054974 A2。
  • HY-107051
    GW 766994 Antagonist
    GW 766994 是趋化因子受体-3 (chemokine receptor-3) 拮抗剂,已经进入临床阶段,研究哮喘和嗜酸性支气管炎。
  • HY-15724
    Vercirnon Antagonist 98.04%
    Vercirnon是一种高效的CCR9拮抗剂, 在Molt-4细胞、CCR9转染细胞系、原代人T细胞、及鼠胸腺细胞,抑制CCR9介导的CCL25趋化 (IC50<7 nM)。
  • HY-15418
    RS 504393 Antagonist 98.58%
    RS 504393 是一种选择性的 CCR2 拮抗剂,作用于人重组 CCR2b 和 CCR1 受体,IC50 值分别为 98 nM 和 > 100 μM。
  • HY-13406
    TAK-779 Antagonist 99.73%
    TAK-779是高活性非肽类CCR5选择性拮抗剂,IC50为1.4 nM,还能抑制HIV-1的Ba-L株在MAGI-CCR5和PBMC中的复制,EC50 分别为1.2和3.7 nM。
  • HY-18611
    RS102895 hydrochloride Antagonist 98.98%
  • HY-101713
    CCX140 Inhibitor 98.08%
  • HY-50669A
    MK-0812 Succinate Antagonist 99.57%
  • HY-15450A
    INCB 3284 Antagonist 99.30%
    INCB 3284是趋化因子受体CCR2高选择性拮抗剂,IC50值为3.7nM。
  • HY-U00064
    AZD2098 Inhibitor 99.85%
    AZD2098 是 CCR4 的有效抑制剂,可用于治疗哮喘研究。
  • HY-14882A
    Cenicriviroc Mesylate Antagonist 98.23%
    Cenicriviroc 是一种双重 CCR2/CCR5 拮抗剂。
  • HY-17377
    Vicriviroc maleate Antagonist 99.41%
    Vicriviroc (Sch-417690)马来酸盐是CCR5拮抗剂,IC50为0.91 nM,可作用于HIV-1。
  • HY-19974
    TAK-220 Antagonist >98.0%
  • HY-50669
    MK-0812 Antagonist 99.75%
    MK-0812 是一种有效的选择性的 CCR2 拮抗剂,作用于人单核细胞,对 CCR2 具有低 nM 的亲和力。
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