1. Protein Tyrosine Kinase/RTK
  2. c-Fms

c-Fms

c-FMS (CSF1R) is located at the cell plasma membrane. c-FMS is the receptor for the ligand colony stimulating factor-1 (CSF1). c-FMS is an integral transmembrane glycoprotein that exhibits ligand-induced tyrosine-specific protein kinase activity, which triggers a signaling cascade eventually affecting transcription of CSF1-responsive genes. c-FMS tyrosine phosphorylation is induced upon binding of CSF1, leading to activation of Ras/Erk and class I-A phosphatidylinositol 3-kinase signaling pathways, which in turn activate the signal transducers and activators of transcription (STATs) pathways, specifically STAT1, STAT3, and STAT5. c-FMS activation by CSF1 results in increased growth, proliferation and differentiation.

c-Fms 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-16749
    Pexidartinib Inhibitor 98.86%
    Pexidartinib 是 KIT,CSF1R 和 FLT3 的抑制剂,能够作用于 Fms 和 Kit,IC50 分别为 28 和 16 nM。
  • HY-12768
    BLZ945 Inhibitor 98.57%
    BLZ945 是一种可渗透脑的 CSF-1R 抑制剂,IC50 为 1 nM。
  • HY-10917
    GW2580 Inhibitor 99.34%
    GW2580 是一种选择性的 CSF-1R 抑制剂,能够抑制 c-FMS 活性,IC50 值为 30 nM,对其选择性是对 b-Raf,CDK4,c-KIT,c-SRC,EGFR,ERBB2/4,ERK2,FLT-3,GSK3,ITK,JAK2 等的 150-500 倍。
  • HY-12009
    Pazopanib Hydrochloride Inhibitor 99.92%
    Pazopanib(GW-786034)盐酸盐是多靶点抑制剂,对VEGFR1,VEGFR2,VEGFR3,PDGFR,FGFR,c-Kit和c-Fms的IC50分别为10 nM,30 nM,47 nM,84 nM,74 nM,140 nM和146 nM。
  • HY-10408
    Ki20227 Inhibitor 99.45%
    Ki-20227是CSF1R抑制剂,IC50为2 nM,对VEGFR2的IC50为12 nM,对c-Kit/PDGFRβ的IC50则为451/217 nM。
  • HY-13838
    PLX647 Inhibitor
    PLX647是FMS/KIT双重抑制剂,IC50值分别为28和16nM。
  • HY-10204
    OSI-930 Inhibitor 99.82%
    OSI-930是Kit,KDR和CSF-1R的抑制剂,IC50分别为80 nM,9 nM和15 nM,对Flt-1,c-Raf和Lck有接近的抑制性,但对 PDGFRα/β,Flt-3和Abl抑制性较弱。
  • HY-13075
    c-FMS inhibitor Inhibitor 99.39%
    c-FMS抑制剂是c-Fms激酶抑制剂,具有抗炎抗风湿活性。