1. Protein Tyrosine Kinase/RTK
  2. c-Fms

c-Fms

c-FMS (CSF1R) is located at the cell plasma membrane. c-FMS is the receptor for the ligand colony stimulating factor-1 (CSF1). c-FMS is an integral transmembrane glycoprotein that exhibits ligand-induced tyrosine-specific protein kinase activity, which triggers a signaling cascade eventually affecting transcription of CSF1-responsive genes. c-FMS tyrosine phosphorylation is induced upon binding of CSF1, leading to activation of Ras/Erk and class I-A phosphatidylinositol 3-kinase signaling pathways, which in turn activate the signal transducers and activators of transcription (STATs) pathways, specifically STAT1, STAT3, and STAT5. c-FMS activation by CSF1 results in increased growth, proliferation and differentiation.

c-Fms 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-16749
    Pexidartinib Inhibitor 99.23%
    Pexidartinib (PLX-3397)是多靶点受体酪氨酸激酶抑制剂, 抑制 CSF1Rc-KitFLT3IC50 分别为13 nM,27 nM,11 nM。
  • HY-12768
    BLZ945 Inhibitor 99.56%
    BLZ945是一种有效,选择性和脑渗透性的 CSF-1R 抑制剂,IC50为1 nM,选择性是其他受体酪氨酸激酶同系物的1000倍。
  • HY-10917
    GW2580 Inhibitor 98.45%
    GW2580是可口服的 c-Fms 激酶抑制剂,体外实验中在0.06 μM时可完全抑制人cFMS激酶。
  • HY-12009
    Pazopanib Hydrochloride Inhibitor 99.92%
    Pazopanib (GW786034) 是多靶点抑制剂,抑制 VEGFR1VEGFR2VEGFR3PDGFRβc-KitFGFR1c-FmsIC50分别为10,30,47,84,74,140,146 nM。
  • HY-10204
    OSI-930 Inhibitor
    OSI-930是Kit,KDR和CSF-1R的抑制剂,IC50分别为80 nM,9 nM和15 nM,对Flt-1,c-Raf和Lck有接近的抑制性,但对 PDGFRα/β,Flt-3和Abl抑制性较弱。
  • HY-10408
    Ki20227 Inhibitor 99.30%
    Ki-20227是CSF1R抑制剂,IC50为2 nM,对VEGFR2的IC50为12 nM,对c-Kit/PDGFRβ的IC50则为451/217 nM。
  • HY-13838
    PLX647 Inhibitor 98.20%
    PLX647是FMS/KIT双重抑制剂,IC50值分别为28和16nM。
  • HY-18787
    cFMS-IN-2 Inhibitor 99.05%
    cFMS-IN-2 是一种 FMS 激酶抑制剂,其 IC50 值为 0.024 μM。
  • HY-13075
    c-FMS inhibitor Inhibitor 99.39%
    c-FMS抑制剂是c-Fms激酶抑制剂,具有抗炎抗风湿活性。
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