1. Protein Tyrosine Kinase/RTK
  2. DYRK

DYRK

Mammalian DYRKs are a subfamily of mitogen-activated protein kinase-related protein kinases and are originally discovered on the basis of homology to the Saccharomyces cerevisiae Yak1 and Drosophila mini-brain kinases. DYRKs possess Ser/Thr phosphorylation activity as well as autophosphorylation activity on Tyr residue(s).

Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells. Co-expression of DYRK1A, DYRK1B, or DYRK2 with a series of glycogen synthase mutants with Ser/Ala substitutions at the phosphorylation sites in COS cells revealed that protein kinases cause phosphorylation of site 3a in glycogen synthase. Control of glycogen synthase by DYRK represents a novel mechanism, and a potentially novel pathway, for the regulation of glycogen synthesis.

DYRK 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-12277
    AZ191 Inhibitor 99.03%
    AZ191是DYRK1B高效选择性抑制剂,IC50值17nM。
  • HY-15838
    ID-8 Inhibitor >98.0%
    ID-8是DYRK抑制剂,长时间培养可维持胚胎干细胞的自我更新。
  • HY-12838
    Mirk-IN-1 Inhibitor 98.53%
    Mirk-IN-1(Dyrk1B/A-IN-1)是Dyrk1B和Dyrk1A高效选择性抑制剂,IC50值分别为68和22nM。