1. Protein Tyrosine Kinase/RTK
  2. ALK

ALK

ALK (Anaplastic lymphoma kinase) is encoded by the ALK gene. ALK is a membrane associated tyrosine kinase receptor of the insulin receptor superfamily. The function of the full-length ALK receptor is poorly understood. It has a probable role in the central and peripheral nervous system development and maintenance. ALK is a dependence receptor, which may exert antagonist functions, proapoptotic or antiapoptotic, depending on the absence or presence of a ligand. Dependence receptors have a potential role in cancer and development. Ligands available for this demonstration were agonist anti-ALK antibodies. ALK is still an orphan receptor, given the high level of controversy about pleiotrophin and midkine.

ALK 相关产品 (29):

Cat. No. Product Name Effect Purity
  • HY-50878
    Crizotinib Inhibitor 99.97%
    Crizotinib 是一种有效的 c-MetALK 的抑制剂,IC50 值分别为 11 nM 和 24 nM。
  • HY-12857
    Brigatinib Inhibitor 99.86%
    Brigatinib 是一种有效的,选择性的 ALK 抑制剂,IC50 值为 0.6 nM。
  • HY-12215
    PF-06463922 Inhibitor 99.83%
    PF-06463922 是一种有效的,ALK/ROS1 双重抑制剂,抑制 ROS1,ALK (野生型) 和 ALK (L1196M),Ki 分别为 < 0.02 nM,< 0.07 nM 和 0.7 nM。
  • HY-15656
    LDK378 Inhibitor 99.95%
    LDK378 是一种有效的特异性 ALK 抑制剂,IC50 为 0.2 nM。
  • HY-13011
    CH5424802 Inhibitor 99.34%
    CH5424802 是一种口服有效的选择性的 ALK 抑制剂,IC50 为 1.9 nM。
  • HY-103714A
    X-396 hydrochloride Inhibitor 98.51%
    X-396 hydrochloride 是一种有效的双重的 ALK/MET 抑制剂,IC50 分别 <0.4 nM 和 0.74 nM。
  • HY-112140
    JH-VIII-157-02 Inhibitor 98.86%
    JH-VIII-157-02 是 alectinib 的结构类似物,为 ALK 抑制剂,对棘皮动物微管相关蛋白样 4 (EML4)-ALK G1202R 的 IC50 值为 2 nM。
  • HY-103714
    X-396 Inhibitor
    X-396 是一种有效的双重的 ALK/MET 抑制剂,IC50 分别 <0.4 nM 和 0.74 nM。
  • HY-12678
    Entrectinib Inhibitor 99.61%
    Entrectinib是有效的,有口服活性的Trk, ROS1, 和ALK抑制剂;抑制TrkA, TrkB, TrkC, ROS1和 ALK的IC50值分别为1, 3, 5, 12 和7 nM。
  • HY-13011A
    CH5424802 Hydrochloride Inhibitor 99.95%
    CH5424802盐酸盐(AF 802 Hcl; Alectinib Hcl)是ALK激酶高效抑制剂,IC50值为1.9nM,对ALK突变型L1196M也敏感。
  • HY-50878A
    Crizotinib hydrochloride Inhibitor 99.86%
    Crizotinib hydrochloride is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively.
  • HY-10192
    NVP-TAE 684 Inhibitor 99.40%
    NVP-TAE 684 是一种高效的,选择性的 ALK 抑制剂,阻止 ALCL 衍生的 ALK 依赖性细胞株的生长,IC50 值为 2-10 nM。
  • HY-15656A
    LDK378 dihydrochloride Inhibitor 99.86%
    LDK378 2Hcl是ALK抑制剂,IC50为0.2 nM,比对IGF-1R和InsR的抑制性高40倍和35倍。
  • HY-16590
    X-376 Inhibitor 98.02%
    X-376 是一种有效的双重的 ALK/MET 抑制剂,IC50 分别为 0.61 nM 和 0.69 nM。
  • HY-15609
    AZD-3463 Inhibitor 98.49%
    AZD-3463是ALK/IGF1R抑制剂。
  • HY-103022
    TPX-0005 Inhibitor 99.91%
    TPX-0005 是一种有效的 ALK/ROS1/TRK 抑制剂,对 SRC,野生型 WT ALK,突变型 ALK G1202R 和 ALK L1196M 的 IC50 值分别为 5.3 nM,1.01 nM,1.26 nM 和 1.08 nM。
  • HY-15841
    CEP-37440 Inhibitor 99.87%
    CEP-37440是新型FAK和ALK双重抑制剂,IC50分别为2.3 nM和120 nM。
  • HY-13464
    ALK-IN-1 Inhibitor 99.96%
    ALK-IN-1是ALK激酶高效选择性抑制剂,出自专利US20140066406 A1。
  • HY-13326
    ASP3026 Inhibitor 99.76%
    ASP3026是高活性ALK抑制剂,IC50为3.5 nM。
  • HY-13020
    GSK1838705A Inhibitor 98.99%
    GSK1838705A是高效,可逆的 IGF-IR 和胰岛素受体 (insulin receptor) 抑制剂,IC50 值分别为2.0 和 1.6 nM。也可抑制 ALKIC50 值为0.5 nM。
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