1. GPCR/G Protein
  2. CRFR

CRFR

CRFR (Corticotropin-releasing Factor Receptor), also known as corticotropin-releasing hormone receptor (CRHR), belongs to the G protein-coupled receptor family. There are 3 types of this recetpor, CRF1, CRF2 and CRF3 receptor. CRF1 receptor (CRF1 or CRF) is functionally coupled to adenylate cyclase and it belongs to the secretin-like, family B of GPCRs. CRF1 receptor has several splice variants (CRF1c-CRF1m) including CRF. CRF2 receptor is a 411-amino acid protein with approximately 70% identity to the known CRF1 and it is functionally coupled to adenylate cyclase. The CRF2 receptor has been shown to be expressed as three functional splice variants, the CRF (411-413 amino acids), the CRF (431-438 amino acids) and the CRF (397 amino acids). CRF3 receptor is a 428-amino acid protein, which binds CRF with a 5-fold higher affinity than URO and SVG and is expressed in the pituitary gland, urophysis, and brain.

CRFR subserves central functions related to stress physiology, and also exerts peripheral actions relevant to cardiovascular, muscular, gastrointestinal, pancreatic, inflammatory, and neoplastic diseases.

CRFR 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-14127
    R121919 Antagonist 99.46%
    R121919是一种高效的小分子CRF1受体拮抗剂。对于CRF1受体的Ki值为2至5 nM,对CRF2受体,CRF结合蛋白或70种其它受体类型的活性弱超过1000倍。
  • HY-14130
    CP 376395 Antagonist 99.53%
    CP 376395是有效和选择性的 CRF1 受体拮抗剂。
  • HY-14875
    Verucerfont Antagonist 99.94%
    Verucerfont 是促肾上腺皮质激素释放因子受体 1 (CRF1) 的拮抗剂,对于 CRF1,CRF2 和 CRF-BP 的 IC50 值分别为 6.1,>1000 和 >1000 nM。
  • HY-12127
    Pexacerfont Antagonist
    Pexacerfont 是一种选择性的促肾上腺皮质激素释放因子 (CRF1) 受体拮抗剂,作用于人 CRF1 受体,IC50 为 6.1±0.6 nM。
  • HY-14129
    CP 316311 Antagonist
    CP 316311 是一种有效的,选择性的 CRF1 receptor 拮抗剂,IC50 值为 6.8 nM。
  • HY-P1542
    Urotensin I Agonist
    Urotensin I 是由 41 个氨基酸组成的神经肽,结构与 CRF 类似,可与 CRF 受体结合,在细胞实验中,对人 CRF1,CRF2 和大鼠 CRF 受体的 pEC50 值分别为 11.46,9.36 和 9.85,对 hCRF1,rCRF 和 mCRF 受体的 Ki 值分别为 0.4,1.8 和 5.7 nM。
  • HY-P1295
    Urocortin, human Agonist
    Urocortin, human 是由 40 个氨基酸组成的神经多肽,为选择性的 CRF2 受体激动剂,对 hCRF1,rCRF 和 mCRFKi 值分别为 0.4,0.3 和 0.5 nM。
  • HY-P1296
    Urocortin, rat Agonist
    Urocortin, rat 是一种选择性的 CRF receptor 受体激动剂,对 hCRF1,rCRF 和 mCRFKi 值分别为 0.32,2.2 和 0.62 nM。
  • HY-12339
    NVS-CRF38 Antagonist
    NVS-CRF38是一新型CRF1受体拮抗剂,较低的水溶性。
  • HY-14367
    Emicerfont Antagonist
    Emicerfont 是一个促肾上腺皮质激素释放因子 1 型 (CRF1) 受体拮抗剂,其 IC50 值为 66 nM。
  • HY-P1533
    CRF,bovine Agonist
    CRF,bovine 是一种有效的 CRF 受体激动剂,能够取代 [125I-Tyr]ovine CRF,Ki 值为3.52 nM。
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