1. Cell Cycle/DNA Damage
  2. APC

APC

APC (Anaphase-Promoting Complex) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. The APC/C's main function is to trigger the transition from metaphase to anaphase by tagging specific proteins for degradation. The two proteins of most importance that get degraded in this process as substrates of the APC/C are securin and S and M cyclins. Securin releases separase, a protease, after being degraded which in turn triggers the cleavage of cohesin, the protein complex that binds sister chromatids together. During metaphase, sister chromatids are linked by intact cohesin complexes. When securin undergoes ubiquitination by the APC/C and releases separase, which degrades cohesin, sister chromatids become free to move to opposite poles for anaphase. The APC/C also targets the mitotic cyclins for degradation, resulting in the inactivation of M-CdK (mitotic cyclin-dependent kinase) complexes, promoting exit from mitosis and cytokinesis.

APC 相关产品 (1):

Cat. No. Product Name Effect Purity
  • HY-13255
    TAME Inhibitor 99.11%
    TAME 是一种 APC 抑制剂,可通过作用于 Cdc20 和 Cdh1 来抑制 APC 的活性;TAME 同时为处于有丝分裂期非洲爪蟾蜍卵提取物的细胞周期蛋白的水解抑制剂,IC50 值为 12 µM。
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