1. GPCR/G Protein
  2. GPR119

GPR119

GPR119 (G protein-coupled receptor 119) is a G protein-coupled receptor that in humans is encoded by the GPR119 gene. GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors. GPR119 is expressed predominantly in the pancreas and gastrointestinal tract in rodents and humans, as well as in the brain in rodents. Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats. GPR119 has also been shown to regulate incretin and insulin hormone secretion. As a result, new drugs acting on the receptor have been suggested as novel treatments forobesity and diabetes.

GPR119 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-15564
    AR 231453 Agonist 99.49%
    AR231453是GPR119激动剂,能增强葡萄糖依赖的胰岛素分泌和GLP-1释放。
  • HY-15291
    MBX-2982 Agonist 99.39%
    MBX-2982 是一种口服选择性的 G 蛋白偶联受体 119 (GPR119) 激动剂。
  • HY-12066
    GSK1292263 Agonist 98.14%
    GSK1292263是PR119受体激动剂,可用于2型糖尿病。
  • HY-16673
    PSN632408 Agonist 99.13%
    PSN632408是GPR119受体激动剂,与内源性配体OEA活性接近,对重组型鼠和人的GPR119受体的EC50分别为5.6和7.9 uM。
  • HY-15566
    APD597 Agonist >98.0%
    APD597是GPR119激动剂, 作用于hGPR119, EC50为46 nM, 可用于治疗2型糖尿病。
  • HY-15565
    APD668 Agonist 99.16%
    APD668是GPR119激动剂,对人GPR119和大鼠GPR119的EC50分别为2.7 nM和33 nM。