1. NF-κB
  2. Keap1-Nrf2

Keap1-Nrf2

Keap1-Nrf2 is the major regulator of cytoprotective responses to oxidative and electrophilic stress. Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Such sequestration and further degradation of Nrf2 in the cytoplasm are mechanisms for the repressive effects of Keap1 on Nrf2. because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.

Keap1-Nrf2 相关产品 (15):

Cat. No. Product Name Effect Purity
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    Bardoxolone methyl Activator 98.59%
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    Curcumin Activator 99.68%
    Curcumin 是一种天然的酚类化合物,具有显著的抗氧化作用,通过激活 Nrf2 来起到化疗作用。
  • HY-14909
    Bardoxolone Activator 99.21%
    Bardoxolone 是一种 新型核调节因子 (Nrf-2)激活剂。
  • HY-17376
    Ezetimibe Activator 99.76%
    Ezetimibe 是一种 NPC1L1 抑制剂,是有效的 Nrf2 激活剂,Ezetimibe (Eze) 是有效的胆固醇吸收抑制剂。
  • HY-100523
    ML385 Inhibitor 99.59%
    ML385是新颖特异性的NRF2抑制剂。
  • HY-B2230
    Hinokitiol Inhibitor
    Hinokitiol 是从日本扁柏中分离到的挥发油成分,具有抗感染、抗氧化及抗肿瘤等活性。
  • HY-12213
    CDDO-EA Activator 99.32%
    CDDO-EA 是一种 NF-E2 相关因子 2 /抗氧化反应元件 (Nrf2/ARE) 激活剂。
  • HY-17363
    Dimethyl fumarate Activator >98.0%
    Dimethyl fumarate 是一种 Nrf2 激活剂,能够诱导上调抗氧化基因的表达。
  • HY-12212
    RTA-408 Activator 98.96%
    RTA-408是转录因子Nrf2活化剂,能抑制免疫转录因子NF-kB。
  • HY-N0780
    Isoalantolactone Activator 99.92%
    异土木香内酯 (Isoalantolactone) 是从土木香中分离到的天然化合物,能够抑制多种肿瘤细胞的生长,并能够抑制由电击导致的小鼠强直性发作,EC50: 336 (285–396) mg/kg。
  • HY-N0198
    Nordihydroguaiaretic acid Activator 99.31%
    Nordihydroguaiaretic acid (NDGA)是一种由石炭酸灌木Larrea divaricata提取的天然酚类化合物,在体内外均具有抗肿瘤活性。其类似物可作用于难治性实体肿瘤。
  • HY-19734
    NK-252 Activator 99.29%
    NK-252是Nrf2激活剂,和OPZ相比有更强的激活能力更强。
  • HY-N1913
    Danshensu Activator >98.0%
    Danshensu 是丹参的有效成分,能够激活 Nrf2 信号通路,保护心血管。
  • HY-N0553
    Gypenoside XVII Activator
    七叶胆苷XVII (Gypenoside XVII) 是一种天然化合物。
  • HY-17376S
    Ezetimibe D4
    Ezetimibe D4是Ezetimibe的氘代化合物标准品。